Trauma Center Grant Publications

Presented at the American College of Surgeons, October, 2011

  1. Sheu EG, Wakatsuki K, Younan G, Oakes SM, Moore FD, Jr. Ischemic Injury Inhibits Cancer Metastasis by Modulation of Host Adaptive Immunity. 3 Sept 2011. JACS 213(3):S137.
  2. Sheu EG, Wei J, Ma M, Carroll MC, Moore FD, Jr. Characterization of the Human Peritoneal Lymphocyte Compartment and Its Antibody Repertoire. 3 Sept 2011. JACS 213(3):S57-8.

Presented at the Academic Surgical Congress, February, 2011

  1. Wakatsuki K, Sheu EG, Oakes SM, Moore FD Jr. T Lymphocytes Promote Tumor Growth Following Ischemia-Reperfusion Injury.
  2. Sheu EG, Oakes SM, Carroll MC, Moore FD Jr. Isolation Of Antibody Producing Human Peritoneal B Lymphocytes That Modulate Ischemia-Reperfusion Injury.
  3. Younan G, Sheu EG, Dagher W, Oakes SM, Moore FD Jr. Human Serum Aggravates Injury In A Human Skin Xenograft Scald Burn Model.

Abstract Accepted

  1. Torabi R, Barone A, Kim K, Younan G, Haas M, Smith R, Austen KF, Moore FD Jr., Carroll MC, Austen WG, Sachs DH, Cetrulo CL. Abrogation of Ischemia-Reperfusion Injury In Composite Tissue Allografts.


Leto Barone AA, Zhou ZY, Hughes MW, Park R, Schulman RM, Lee S, Vidar EN, Shiba TL, Weber EL, Cetrulo CL Jr. Lentiviral transduction of face and limb flaps: implications for immunomodulation of vascularized composite allografts. Plast Reconstr Surg. 2012 feb;129(2):391-400. PMID:22286422.

Leonard DA, Gordon CR, Sachs DH, Cetrulo CL Jr. Immunobiology of face transplantation. J Craniofac Surg 2012;23:268-271.

Rutemark C, Alicot E, Bergman A, Ma M, Getahun A, Ellmerich S, Carroll MC, Heyman B. Requirement for complement in antibody responses is not explained by the classic pathway activator IgM. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E934-42. PMCID:PMC3203774(Available on 2012/4/25).

Xing W, Austen KF, Gurish MF, Jones TG. Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice regulated by the tissue. Proc Natl Acad Sci U. S. A. 2011 Aug 23;108(34):14210-14215. PMCID:PMC3161524 (Available on 2012/2/23).

Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD Jr., Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15;185(12):7681-90. PMCID:PMC3058366.

Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovasc Res 2010 87:618-627. PMCID:PMC2920809.

Afnan J, Ahmadi-Yazdi C, Sheu EG, Oakes SM, Moore FD Jr. Inhibition of rat gut reperfusion injury with an agent developed for the mouse. Evidence that amplification of injury by innate immunity is conserved between two animal species. Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1675-81. PMCID:PMC2886695.

Sheu EG, Oakes SM, Ahmadi-Yazdi C, Afnan J, Carroll MC, Moore FD Jr. Restoration of skeletal muscle ischemia-reperfusion injury in humanized immunodeficient mice. Surgery. 2009 Aug;146(2):340-6. PMCID:PMC2767199.

Ahmadi-Yazdi C, Williams B, Oakes S, Moore FD Jr. Attenuation of the effects of rat hemorrhagic shock with a reperfusion injury-inhibiting agent specific to mice. Shock. 2009 Sep;32(3):295-301. PMCID:PMC2993186.

Suber F, Carroll MC, Moore FD Jr. Innate response to self-antigen significantly exacerbates burn wound depth. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3973-7. PMCID:PMC1820693.

Chan RK, Ibrahim SI, Takahashi K, Kwon E, McCormack M, Ezekowitz A, Carroll MC, Moore FD Jr, Austen WG Jr. The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemian reperfusion. J Immunol. 2006 Dec 1;177(11):8080-5.

Zhang M, Takahashi K, Alicot EM, Vorup-Jensen T, Kessler B, Thiel S, Jensenius JC, Ezekowitz RA, Moore FD, Carroll MC. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J Immunol. 2006 Oct 1;177(7):4727-34.

Zhang M, Michael LH, Grosjean SA, Kelly RA, Carroll MC, Entman ML. The role of natural IgM in myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2006 Jul;41(1):62-7.

Chan RK, Verna N, Afnan J, Zhang M, Ibrahim S, Carroll MC, Moore FD Jr. Attenuation of skeletal muscle reperfusion injury with intravenous 12 amino acid peptides that bind to pathogenic IgM. Surgery. 2006 Feb;139(2):236-43.

Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23;203(1):141-52. PMCID:PMC2118091.

Abonia JP, Friend DS, Austen WG Jr, Moore FD Jr, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005 Jun 1;174(11):7285-91.

Chan RK, Austen WG Jr, Ibrahim S, Ding GY, Verna N, Hechtman HB, Moore FD Jr. Reperfusion injury to skeletal muscle affects primarily type II muscle fibers. J Surg Res. 2004 Nov;122(1):54-60.

Chan RK, Ding G, Verna N, Ibrahim S, Oakes S, Austen WG Jr, Hechtman HB, Moore FD Jr. IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion. J Surg Res. 2004 Nov;122(1):29-35.

Austen WG Jr, Zhang M, Chan R, Friend D, Hechtman HB, Carroll MC, Moore FD Jr. Murine hind limb reperfusion injury can be initiated by a self-reactive monoclonal IgM. Surgery. 2004 Aug;136(2):401-6.

Zhang M, Austen WG Jr, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD Jr, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3886-91. PMCID:PMC374339.

Chan RK, Ibrahim SI, Verna N, Carroll M, Moore FD Jr, Hechtman HB. Ischaemia-reperfusion is an event triggered by immune complexes and complement. Br J Surg. 2003 Dec;90(12):1470-8. Review.

Austen WG Jr, Kobzik L, Carroll MC, Hechtman HB, Moore FD Jr. The role of complement and natural antibody in intestinal ischemia-reperfusion injury. Int J Immunopathol Pharmacol. 2003 Jan-Apr;16(1):1-8. Review.

Reid RR, Woodcock S, Shimabukuro-Vornhagen A, Austen WG Jr, Kobzik L, Zhang M, Hechtman HB, Moore FD Jr, Carroll MC. Functional activity of natural antibody is altered in Cr2-deficient mice. J Immunol. 2002 Nov 15;169(10):5433-40.