Regenerative Medicine Laboratory

Sinha Lab - Skeletal Muscle Regeneration, Skin Regeneration and Wound Healing

Indranil Sinha, MD
Assistant Professor, Harvard Medical School
isinha@partners.org
Principal Investigator, Skeletal Muscle Regeneration

Kristo Nuutila, MSc, PhD
Instructor, Harvard Medical School
knuutila@partners.org
Principal Investigator, Skin Regeneration and Wound Healing

Lab Contact Information

Dharaniya Sakthivel, MS
75 Francis Street
Boston, MA 02115
Phone: 617-732-4836
dsakthivel@partners.org

Research Information

Interests

  • Skeletal Muscle Regeneration
  • Skin Regeneration and Wound Healing

Active Projects

Skeletal Muscle Regeneration to improve function following traumatic injury.  
Following trauma, skeletal muscle heals with fibrosis and scarring rather than appropriate skeletal muscle regeneration. Our lab is studying the use of biologic scaffolds and purified skeletal muscle precursors to help heal these wounds with functional muscle rather than scarring. A similar approach is being applied to skeletal muscle regeneration following ischemia reperfusion injury.

Evaluation of the hypoxia pathway in Diabetic muscle regeneration. 
Multiple studies have demonstrated that skeletal muscle regenerates poorly following injury. Our lab is actively investigating the involvement of the hypoxia pathway in this healing cascade and evaluating multiple pharmacologic agents that may be used to reverse this process.

Optimization of a skin wound microenvironment for better skin regeneration.
The wound microenvironment is a unique entity that determines the fate of the wound. In an optimal environment the wound heals fast with minimal scarring while unfavorable conditions may impair the healing process and cause fibrosis and scarring. The goal of our laboratory is to study the roles of different factors in the wound microenvironment to optimize the conditions for better healing and thus aim for more targeted treatments.

Transplantation of skin particles and cells to regenerate full-thickness wounds.
Full-thickness wound healing requires both dermal and epidermal components in order to heal through regeneration instead of repair that might result in fibrotic tissue and scarring. Transplantation of cells and skin particles is one of the methodologies that are being used in the laboratory. The goal is to find alternative and better methods to support the current standard of care in the treatment of full-thickness wounds.

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