Matthew Spite, PhD, Principal Investigator

Dr. Spite is an Associate Professor at Harvard Medical School and a Lead Investigator in the Center for Experimental Therapeutics and Reperfusion Injury (CETRI), Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women’s Hospital. He is also the Co-Director of the CETRI metabolipidomics-core. His research focuses on the role of lipid mediators in inflammation. As a postdoctoral fellow with Dr. Charles Serhan, he contributed to the structural elucidation of lipid mediators that promote the resolution of acute inflammation (i.e., resolvin D2 and maresin 1) and maintains an active independent research program that seeks to understand the role of these “pro-resolving mediators” in innate immunity, vascular biology and tissue repair.

His group is also interested in understanding whether defects in pro-resolution pathways contribute to chronic inflammation in cardiovascular and metabolic disease, and whether pro-resolving mediators could be used as templates to develop novel therapeutics for chronic inflammatory diseases.

Spite Lab Website

Selected References

Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M. Biosynthesis of D-series resolvins in skin provides insights into their role in tissue repair. (2018) J. Invest. Dermatol. (In press).

Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA, Spite M Resolvin D2 enhances post-ischemic revascularization while resolving inflammation. (2016) Circulation 134:666-80

Sansbury BE, Spite M. Resolution of acute inflammation and the role of resolvins in immunity, thrombosis and vascular biology. (2016) Circ. Res. 119:113-30

Varga T, Mounier R, Patsalos A, Gogolak P, Peloquing M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E, Poliska S, Cuvellier S, Larbi SB, Alvarado G, Sansbury BE, Spite M, Brown CW, Chazaud B, Nagy L. PPARγ in repair macrophages controls GDF3 and skeletal muscle regeneration. (2016) Immunity 45:1038-1051

Fredman G, Hellmann J, Proto J, Kuriakose G, Colas R, Dorweiler B, Connolly E, Solomon R, Heyer E, Jones D, Spite M*, Tabas I. An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. (2016) Nat. Comm. 7:12859. *Co-corresponding author

Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I MerTK cleavage limits pro-resolving mediator biosynthesis and exacerbates tissue inflammation. (2016) Proc. Natl. Acad. Sci. 113:6526-31.

Spite M, Claria J, Serhan CN Resolvins, specialized pro-resolving lipid mediators and their potential roles in metabolic diseases. (2013) Cell Metab. 19: 21-36

Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M Pro-resolving therapy for the treatment of delayed healing of diabetic wounds. (2013) Diabetes 62:618-27.

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. (2009) Nature 461:1287-1291.

Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent anti-inflammatory and pro-resolving actions. (2009) J. Exp. Med. 206: 15-23.

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Lab Members

Matthew Spite, PhD

Matthew Spite, PhD

Principal Investigator

Agustina Mena

Agustina Mena

Postdoctoral Fellow

Blenda Wong

Blenda Wong

Laboratory Manager

Jake Altomare

Jake Altomare

Research Technician