Anesthesiology, Perioperative and Pain Medicine Research

A MESSAGE FROM THE VICE CHAIRMAN FOR RESEARCH

J. Danny Muehlschlegel, MDWelcome to the research home of the Brigham Health Department of Anesthesiology, Perioperative, and Pain Medicine. The Department is involved in laboratory, translational, and clinical research at the forefront of academic medicine.

The mission of our research is to understand the mechanisms of diseases and processes that we actively manage and potentially prevent in our patients as they undergo surgeries and other operative procedures. Our aim is to apply this knowledge to the development of new and more effective treatments which can be applied to the clinical practice of anesthesia, intensive care, and pain management, but also to medicine more broadly.

Research in the Department is funded through grants from the National Institutes of Health, Foundations, and Industry and is conducted by both basic scientists and by clinical anesthesiologists. Areas of basic, translational, and clinical research include a broad array of topics, reflecting the diversity, complexity, and reach of the science of Anesthesiology. Departmental investigators frequently collaborate with researchers in other Departments catalyzing the rich scientific environment of Harvard Medical School and its associated hospitals and institutions, and benefit from the longstanding tradition and infrastructure of strong clinical research at Brigham and Women’s Hospital. Fruitful collaborations between industry and departmental investigators, both in the lab and in the operating room have facilitated a strong translational pathway for the development of new drugs and procedures.

Residents and Fellows with interest in laboratory and clinical research are encouraged to pursue their own ideas within the context of our Department's world-renowned research activities and contribute importantly to the success and dissemination of these innovative translational discoveries. To quote our former Chairman Professor Simon Gelman, “Researching, or looking for answers, is unbelievably fun. To make a discovery, no matter how small, is to stand on the top of a mountain, to have a feeling that nobody in the world ever had his or her feet on that mountain. To be a pioneer and a discoverer is an amazing reward in life.”

I encourage you to explore the profiles of the various researchers to fully appreciate the breadth and commitment of our research mission across the Department.

Danny Muehlschlegel, MD, MMSc, FAHA

Vice Chairman for Research
Brigham and Women’s Hospital
Associate Professor of Anesthesiology
Harvard Medical School

 



 

Rearchers (in alphabetical order):

Christopher W. Connor, MD, PhD

Christopher W. Connor, MD, PhD

  • Action of volatile anesthetic gases on neural circuits

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Darin J. Correll, MD

Darin J. Correll, MD

  • Post-operative Pain
  • Opioid Analgesics

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Matthew Friese, MD, PhD

Matthew Friese, MD, PhD

  • Perioperative Cognitive Dysfunction
  • New Cell Signaling Pathways
  • Mechanisms of Postoperative Delerium

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Robert Jamison, PhD

Robert N. Jamison, PhD

  • Psychological Predictors of Chronic Pain
  • Risk Assessment for Misuse of Opioids
  • Role of Innovative Technology in Assessment and Treatment of Pain

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Morteza Mahmoudi, PhD

Morteza Mahmoudi, PhD

  • Nano-structured materials for regenerative medicine
  • Design of cell-imprinted smart nano-patterned substrates
  • Fabrication of novel nanoparticles to combat antibacterial resistance

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J. Danny Muehlschlegel, MD, MSc

J. Danny Muehlschlegel, MD, MSc

  • Genomics of myocardial injury in humans
  • Genetics of Atrial Fibrillation
  • Genetics of Rheumatic Heart Disease

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Srdjan Nedeljkovic, MD

  • Innovative pain therapeutics

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Kristin Schreiber, MD, PhD

Kristin Schreiber, MD, PhD

  • Prediction and Prevention of Postsurgical Pain
  • Evaluating Alternative Analgesic Techniques to Opioids
  • Investigation of Pain Processing Mechanisms

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Charles N. Serhan, PhD, DSc

Charles N. Serhan, PhD, DSc

  • Structural elucidation of novel bioactive molecules for inflammation
  • Pro-resolving therapeutics

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Matthew Spite, PhD

Matthew Spite, PhD

  • Role of lipid mediators in inflammation

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Richard Urman, MD, MBA

Richard Urman, MD, MBA

  • Clinical Trials of New Drugs and Devices
  • Informatics and Database Tools
  • Patient Safety Research
  • Opioid-related Complications

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