Dr. Mahmoudi is a biomedical investigator with a multidisciplinary background in nanomedicine, bioengineering, sensor array, and cardiac cellular biology. His specific research interest is controlling nano-bio interfaces to develop new nano-based therapies for prevention/treatment of life-threatening conditions such as cardiomyopathy, cancer, and neurodegenerative diseases. He and his colleagues have developed several approaches/assays to probe fundamental cell/molecular-nanoparticle interactions, including cell toxicity, cellular labeling, protein corona, personalized protein corona, and metabolome corona ("corona" refers to a coating of various proteins and metabolomes on the surface of nanoparticles). Dr. Mahmoudi has a productive track record of multidisciplinary collaboration, so far yielding ten patents, five books, and over 170 publications with more than 13,500 citations and an h-index of 56.
Development of (nano)structured materials for regenerative medicine. Heart failure is a disease state that begins with injured myocardium, causing subsequent deterioration of the heart’s function and the dilation of its chambers. Heart failure is the leading cause of hospital admission worldwide, and over 5 million people currently suffer from this condition in the US. Unlike many other organs, the adult human heart has limited capability for self-repair. Despite advances in clinical trials, the mortality rate associated with heart failure remains high; and there is still no definitive treatment for this disease. The field therefore urgently needs an alternative efficient therapeutic approach. For the last 5 years, we have been actively working on developing nano-based strategies to introduce novel therapeutic approaches for efficient heart regeneration. (*Corresponding Investigator).
Understanding the implications of the protein corona at the interface of nanoparticles and biological fluids.It is now well accepted that we require a fuller understanding of all major interactions at nano-bio interface to design safe, reliable, and high-yield nanoparticles (NPs) for specific biomedical purposes. To that end, extensive studies have been undertaken to probe every relevant factor at the nano-bio interface. Since 2011, the main goal of my international collaborative research has been to identify and introduce to the scientific community important “hidden factors” factors at the nano-bio interface (e.g., the effect of nanoparticles on environmental health, the concept of Personalized Protein Corona and immune response). These findings may contribute substantially to accelerating the progress of nanoparticle technologies from bench discoveries to clinical use. (*Corresponding Investigator)
Development of sensor array for identification and discrimination of nanoparticles and biomolecules. Array based sensing platforms has emerged a powerful approach toward the detection of wide range of biomolecules. Based on cross-responsive sensor elements, these systems aim to produce composite responses unique to each biomolecule. For the first time in the field, we have developed a sensor array for identification and discrimination of nanoparticles with wide range of physicochemical properties. We have also used sensor array platform for detection of various biomolecules including neurotransmitters. (*Corresponding Investigator)
Design of cell-imprinted smart nano-patterned substrates for controlling stem cell differentiation toward a variety of mature cells. Stem cells have enormous potential therapeutic effects in catastrophic diseases such as cancer, cardiovascular, and neurodegenerative diseases. Substrates with various micro- and nanotopographies have been intensively used to control the differentiations of stem cells. We developed a potentially reliable, reproducible, and cost-effective method for controlling the fate of stem cells by using both micro- and nano-patterned substrates that biomimic cell shapes. These substrates are expected to have a positive translational impact, as they will introduce a novel, chemical-free bioengineering approach for differentiation of stem cells into mature functional cells, for both drug screening and therapeutic applications in a variety of diseases. (*Corresponding Investigator)
Fabrication of novel nanoparticles to combat antibacterial resistance. The combination of patients with poor immune systems, prolonged exposure to anti-infective drugs, and cross-infections has given rise to antibiotic resistance, i.e., nosocomial infections with highly resistant pathogens. After extensive research, we prepared different types of engineered multimodal NPs that are completely compatible with human cells. These NPs comprised a magnetic core and a silver ring with a ligand gap and produced high-yield antibacterial effects and eradication of bacterial biofilms. I served as the primary or corresponding author in all the following studies (*Corresponding Investigator).