Emergency Critical Care Medicine Research

Current Research

Clinical Trials

• Brigham Critical Care Research Consortium and Collaborative (2016)
• A Phase 1b Study of Inhaled CO for the Treatment of Sepsis-Induced ARDS (2023: Baron, Hou)
• 1/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and Sepsis (2023: Baron, Hou)

Observational Studies

• Imputation of PaO2 From SaO2 (2015: Hou)
• Sedation and Hyperoxia: Associations in the Emergency Department (SHAED) (2018: Hou)
• Differences in Prevalence of Transfusion Protocols between Critically Ill Neurologic and Non-Neurologic Patient Populations (2019: Oliveira, Billington, Seethala, Hou, Aisiku)
• Evaluation of acute respiratory distress syndrome in patients enrolled in the Protocolized Care for Early Septic Shock (ProCESS) trial (2021: Oliveira, Hou)
• Correlation of bedside sonographic transhepatic IVC diameter and CVP in patients after cardiac surgery (2021: Oliveira)
• Global Critical Care Scoping Review, International Federation for Emergency Medicine/ World Health Organization (2021: Oliveira)
• Plasma Renin as a Novel Prognostic Biomarker of Sepsis-Associated Acute Respiratory Distress Syndrome (2021: Hou)
• Rapid Antibiotic Profiling and Pathogen IDentification (RAPPID) Study (2021: Hou)
• Extracorporeal Carbon Dioxide Removal for Post-Pneumonectomy Acute Respiratory Distress Syndrome (2022: Ilg, Seethala)
• Cause of Death in Extracorporeal Life Support – A Multi-center Observational Study (2022: Ilg, Seethala)
• Veno-Venous Extracorporeal Membrane Oxygenation Decision Making – A Multi-center Observational Study (2022: Ilg, Seethala)
• Characterization and Predictors of Agitation in Patients with Coronavirus ARDS receiving ECMO – Single Center Observational (2022: Ilg, Seethala)
• An International Characterization of ECMO candidacy Decision Making (2022: Ilg)
• Characterization of Awake Cannulation for VV and VA ECMO: An ELSO Registry Study (2022: Ilg)
• International Research Database for Extracorporeal Support: Index Registry (2022: Ilg, Seethala)
• Analysis of ECMO-Related Safety Reporting (2022: Jansson, Seethala)
• Expert-Level Medical Data Labeling at Scale via a Gamified Crowdsourcing Mobile (2022: Hallisey)
• Emergency Physicians in Critical Care: The 10 years Anniversary of ABIM/ABEM Co-sponsorship for Board Certification in Critical Care Medicine (2022: Sharifali, Hou, Aisiku)
• Evaluating COVID-19 disparities on testing among healthcare personnel during a global pandemic (2022: Aisiku, Hou)
• ProCESS: Race, Ethnicity, and Gender (2022: Hou, Aisiku)
• Racial & Ethnic Disparities in Mortality from Acute Respiratory Failure & Acute Respiratory Distress Syndrome in Mechanically Ventilated Patients (2022: Hou, Aisiku)
• External validation of EDLIPS for the identification of ED patients at high risk of developing ARDS (2022: Char, Hou)
• Early Vasopressor Therapy in Patients with Early Septic Shock: A Subanalysis of the ProCESS Trial (2022: Hou, Aisiku)
• Positive Fluid Balance Worsens Clinical Outcomes in Hospitalized Pneumonia Patients (2022: Hou)
• Accuracy and Efficiency of Computed Tomography Interpretation Between Emergency Physicians and Radiologists for Appendicitis (2022: Hou)
• Adherence to Study Treatment in a Minimal-Contact, Outpatient COVID-19 Clinical Trial (2022: Hou)
• Investigating the Association between Dynamic Driving Pressure and Mortality of COVID-19-related Acute Respiratory Distress Syndrome (ARDS) using Multivariate Joint Models (2022: Hou)
• Effectiveness of an mRNA vaccine booster dose against COVID-19 among U.S. healthcare personnel, October 2021–July 2022 (2022: Hou)
• Using Real-Time Automated Detection and Clinical Decision Support to Improve Lung-Protective Ventilation in Intensive Care (2022-2023: Hou)
• PReventing Emerging infections through Vaccine EffectiveNess Testing II —COVID (Project PREVENT II) (2022-2024: Hou)

Past Research

Clinical Trials

• Protocolized Care for Early Septic Shock (ProCESS) (2008-2014)
• Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications (IRC003) (2010-2017)
• Cardiac Output Monitoring Managing Intravenous Therapy to Treat Emergency Department Severe Sepsis (COMMIT)(2011-2014)
• Lung Injury Prevention Study With Aspirin (LIPS-A) (2012-2016)
• Rapid Administration of Carnitine in sEpsis (RACE) (2013-2018)
• Procalcitonin Antibiotic Consensus Trial (ProACT) (2014-2018)
• Neuromuscular Blockade for Post-Cardiac Arrest Care (NMB_in_CA) (2014-2020)
• PETAL Network: Prevention and Early Treatment of Acute Lung Injury (2014-2021)
• A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension (ATHOS-3) & Expanded Access for LJPC-501 (2015-2018)
• Reevaluation Of Systemic Early neuromuscular blockade (ROSE) (2015-2019)
• Vitamin D to Improve Outcomes by Leveraging Early Treatment (VIOLET) (2017-2019)
• Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD (VENT-AVOID) (2017-2019)
• Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial (2018-2020)
• Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) (2018-2020)
• Study of Efficacy and Safety of MAS825 in Patients With COVID-19 (MAS-COVID) (2020)
• Outcomes Related to COVID-19 Treated with Hydroxychloroquine among In-patients with Symptomatic Disease (ORCHID) (2020)
• A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE) (2020)
• Study of Descartes-30 in Acute Respiratory Distress Syndrome (2020)
• Mesenchymal Stromal Cells in COVID-19 ARDS (2020-2021)
• A Study of Auxora in Patients With Severe COVID-19 Pneumonia (2020-2021)
• COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-79 (2020-2021)
• Randomized Master Protocol for Immune Modulators for Treating COVID-19 (ACTIV-1 IM) (2021)
• Human Intravenous Interferon Beta-Ia Safety and Preliminary Efficacy in Hospitalized Subjects With CoronavirUS (HIBISCUS) (2021)
• Study of Varespladib in Patients Hospitalized With Severe COVID-19 (STAIRS) (2021)
• Novel Experimental COVID-19 Therapies Affecting Host Response (ACTIV-4d RAAS) (2021-2022)

Observational Studies

• Endothelium in Severe Sepsis (2008-2017)
• Lung Injury Prediction Study (USCTG-LIPS1) (2009-2010)
• ProCESS AKI & Late Cardiovascular Consequences (2010-2016)
• FebriDx Clinical Performance (2013-2018)
• Large Observational Study to Understand the Global Impact of Severe Acute Respiratory FailurE (LUNG-SAFE) (2014)
• Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study (2015)
• LOw Tidal volume Universal Support: Feasibility of RecrUitment for Interventional Trial (LOTUS-FRUIT) (2016)
• Early Detection of Inflammatory Biomarkers in Infection (2017-2019)
• Effect of randomization to neuromuscular blockade on physical functional impairment and recovery in ARDS (PRIMROSE) (2017-2020)
• Severe ARDS: Generating Evidence: A Multicenter Observational Study (SAGE) (2017-2021)
• Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient Patients (VIOLET BUD) (2018-2020)
• DIStinguish Respiratory Underlying Pathogen associaTed host response in Acute Respiratory Infection: An Evaluation of FebriDx® POC Test (FebriDx® DISRUPT ACUTE RESPIRATORY INFECTION Trial) (2019-2021)
• PETAL Repository of Electronic Data COVID-19 Observational Study (RED CORAL) (2020)
• Biology and Longitudinal Epidemiology of COVID-19: Observational Study (BLUE CORAL) (2020)
• PReventingEmerging infections through Vaccine EffectiveNess Testing - COVID (PREVENT) (2020-2021)