Neurosurgery Research

The Department of Neurosurgery at Brigham and Women’s Hospital is on the forefront of neuroscience and tumor biology research. With a robust research agenda and state-of-the-art technologies, our program is supported by over 20 research faculty and $10 million in funding each year.

Our laboratories conduct both basic science and clinical research to explore a range of complex neurological diseases, such as brain tumors, spinal disorders, stroke, and epilepsy. The aim of our research is to investigate the underlying risks, treatment strategies, and outcomes associated with these diseases and translate new findings to design and optimize neurosurgical treatments for each of our patients. Our Department works collaboratively on various research projects, as well as with other local, national and international partnering institutes.

Nathalie Agar, PhD

Nathalie Agar, PhD

Focus: Molecular diagnosis and prognosis for clinical and surgical applications

Surgical Molecular Imaging Laboratory

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Fengfeng Bei, PhD

Fengfeng Bei, PhD

Focus: Re-wiring of neural circuits

Bei Laboratory

Wenya Linda Bi, MD, PhD

Wenya Linda Bi, MD, PhD

Focus: Translational biology of skull base tumors by integrating genomic, immunology, advanced imaging, and computational tools to improve patient and surgical outcomes

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Agnieszka Bronisz, PhD

Agnieszka Bronisz, PhD

Focus: Non-coding RNAs and extracellular vesicles in glioblastoma

E. Antonio Chiocca, MD, PhD

E. Antonio Chiocca, MD, PhD

Focus: Novel experimental therapies for malignant brain tumors

Chiocca Laboratory

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Choi-Fong Cho, PhD

Choi-Fong Cho, PhD

Focus: Drug delivery and the blood brain barrier in brain tumors

Elizabeth Claus, MD, PhD

Elizabeth Claus, MD, PhD

Focus: Cancer epidemiology and statistical genetics

Neuro-Epidemiology Laboratory

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Rose Du, MD, PhD

Rose Du, MD, PhD

Focus: Role of genetics in stroke and cerebrovascular diseases

Cerebrovascular Laboratory

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Jakub Godlewski, PhD

Jakub Godlewski, PhD

Focus: The development of novel non-coding RNA (ncRNA) – based therapeutic approaches for glioblastoma multiforme

Godlewski Lab

Alexandra Golby, MD

Alexandra Golby, MD

Focus: Structural and functional MRI and brain electrophysiology

Surgical Brain Mapping Laboratory

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William Gormley, MD, MPH, MBA

William Gormley, MD, MPH, MBA

Focus: To harness the administrative, clinical, research and financial data streams combined with detailed outcomes tracking to inform best practices and protocols for neurosurgery.

Computational Neuroscience Outcomes Center

Sean Lawler, PhD

Sean Lawler, PhD

Focus: Molecular biology and therapy of brain tumors

Yi Lu, MD, PhD

Yi Lu, MD, PhD

Focus: Functional recovery after spinal cord injury

Spinal Cord Injury Research Laboratory

Hiroshi Nakishima, PhD

Hiroshi Nakishima, PhD

Focus: Oncolytic viruses and immunotherapy in glioblastoma

Pier Paolo Peruzzi, MD, PhD

Pier Paolo Peruzzi, MD, PhD

Focus: The biology of small non-coding RNAs and the pioneering of their genetic engineering for a cure against brain cancer.

Khalid Shah, MS, PhD

Khalid Shah, MS, PhD

Focus: Develop and test novel targeted stem cell based therapies for cancer

Center for Stem Cell Therapeutics and Imaging

Timothy R. Smith, MD, MPH, PhD

Timothy R. Smith, MD, MPH, PhD

Computational Neuroscience Outcomes Center

Yanmei Tie, PhD

Yanmei Tie, PhD

Focus: Developing neuroimaging approaches for presurgical brain mapping and investigation of brain function alterations in neurological conditions.

Xin Wang, PhD

Xin Wang, PhD

Focus: Identification of candidate therapeutics for neurodegenerative disorders

Neuroapoptosis Drug Discovery Laboratory

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