Neurosurgery Research Studies

The Department of Neurosurgery at Brigham and Women’s Hospital is a pioneer in neuroscience and is dedicated to the research of neurological disorders including tumor biology, aneurysms, stroke, epilepsy, and spinal disorders.

Below are our current research studies and clinical trials. Please note that not all of the studies are human subject trials. We suggest patient’s reference clinicaltrials.gov for a more complete list of open clinical trials.

For any questions regarding the listed research studies and clinical trials, please reach out to one of our Clinical Research Coordinators at neurosurgerycrc@bwh.harvard.edu

Brain Tumor Research

  • A Phase I Study of the Treatment of Recurrent Malignant Glioma with rQNestin34.5v.2, a Genetically Engineered HSV-1 Virus, and immunomodulation with Cyclophosphamide
    PI: E. Antonio Chiocca, MD, PhD
  • Phase I Study of Neoadjuvant GMCI plus Immune Checkpoint Inhibitor Combined with Standard of Care for Newly Diagnosed High-Grade Gliomas
    PI: E. Antonio Chiocca, MD, PhD
  • Protocol ATI001-102 Substudy: Evaluation of Ad-RTS-hIL-12 + Veledimex in Combination with Nivolumab in Subjects with Recurrent or Progressive Glioblastoma
    PI: E. Antonio Chiocca, MD, PhD
  • Protocol ATI001-102 Expansion Substudy: Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects with Recurrent or Progressive Glioblastoma
    PI: E. Antonio Chiocca, MD, PhD
  • Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier Disruption for the Treatment of High Grade Glioma in Patients Undergoing Standard Chemotherapy
    PI: Alexandra Golby, MD
  • Feasibility of the LUM Imaging System for Intraoperative Detection of Residual Cancer in the Tumor Bed in Subjects with Cancer Metastases to the Brain
    PI: E. Antonio Chiocca, MD, PhD
  • 5-ALA Intraoperative Fluorescence Imaging of Brain Tumors
    PI: Alexandra Golby, MD
  • A Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients with Primary Brain Tumors
    PI: Pier Paolo Peruzzi, MD, PhD

Spine Research

  • Study to Assess the Efficacy and Safety of VX-210 Subjects with Acute Traumatic Cervical Spinal Cord Injury
    PI: Yi Lu, MD, PhD
  • The INSPIRE Study: Probably Benefit of the Neuro-Spinal Scaffold for Treatment of AIS. A Thoracic Acute Spinal Cord Injury
    PI: Yi Lu, MD, PhD
  • A Clinical Study to Assess the Safety and Effectiveness of the Premia Spine TOPS System
    PI: John Chi, MD, MPH
  • The coflex COMMUNITY Study: An Observational Study of coflex Interlaminar Technology
    PI: John Chi, MD, MPH
  • Confirmatory Clinical Study to Support the Effectiveness and Safety of Oxiplex for the Reduction of Pain and Symptoms Following Lumbar Surgery
    PI: John Chi, MD, MPH

Functional Disorders Research

  • ExAblate Transcranial MRgFUS of the Globus Pallidum for Treatment of Parkinson’s Disease
    PI: G. Rees Cosgrove, MD
  • Global Registry: ExAblate 4000 Transcranial MR Guided Focused Ultrasound (TcMRgFUS) of Neurological Disorders
    PI: G. Rees Cosgrove, MD
  • A Pivotal Clinical Trial of the Management of the Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Idiopathic Parkinson’s Disease with Unilateral Lesioning of the Globus Pallidum Using the ExAblate Neuro System
    PI: G. Rees Cosgrove, MD

Cerebrovascular Research

  • ENRICH (Early MiNimally-invasive Removal of ICH)
    PI: M. Ali Aziz-Sultan, MD
  • DEFUSE 3: Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3
    PI: Steven Feske, MD/ M. Aziz-Sultan, MD
  • COMPLETE: International Acute Ischemic Stroke Registry with the Penumbra System Aspiration including the 3D Revascularization Device
    PI: M. Ali Aziz-Sultan, MD

Humanitarian Use Device Research

  • MicroVention Low-profile Visualized Intraluminal Support (LVIS) Device
    PI: M. Ali Aziz-Sultan, MD
  • Codman Neurovascular Enterprise Vascular Reconstruction Device and Delivery System
    PI: Kai Frerichs, MD
  • Wingspan Stent System with Gateway PTA Balloon Catheter for the Treatment of Symptomatic Atherosclerotic Disease for Humanitarian Use
    PI: Kai Frerichs, MD
  • Use of the Neuroform Atlas Stent, a Humanitarian Use Device, for the Treatment of wide-necked Cerebral Aneurysms
    PI: Kai Frerichs, MD
  • PulseRider Aneurysm Neck Reconstruction Device
    PI: M. Ali Aziz-Sultan, MD

Additional Research

  • Behavioral and MRI Studies in Healthy Subjects
    PI: Alexandra Golby, MD
  • Optical Coherence Tomography: Evaluation of the Retinal Thickness and Correlation with Clinical Outcomes after Transsphenoidal Surgery
    PI: Edward Laws, MD
  • Endocrine and Surgical Complications in Pure Endoscopic Endonasal Transsphenoidal Surgery
    PI: Edward Laws, MD
  • Outcomes for Neurosurgical Patients
    PI: Elizabeth Claus, MD, PhD
  • Retrospective Review of Imaging Characteristics of Patients with Dural Arteriovenous Fistulas
    PI: M. Ali Aziz-Sultan, MD
  • Biomarkers in Stroke and Intracerebral Hemorrhage
    PI: Rose Du, MD, PhD
  • The GLIOGENE (Glioma Genetics) Study
    PI: Elizabeth Claus, MD, PhD
  • Risk Factors and Outcomes for Glioma (GLIOGENE International Case/Control Study)
    PI: Elizabeth Claus, MD, PhD
  • Three-Dimensional Angiography for Intraoperative Neuronavigation During Intracranial Tumor Resection: A Technical Note and Case Series
    PI: M. Ali Aziz-Sultan, MD
  • Genetics of Intracranial Vessels
    PI: Rose Du, MD, PhD
  • Gene Expression in Cerebral Aneurysms
    PI: Rose Du, MD, PhD
  • Identification of Delirium Biomarkers Using Multimodal Sensor Data from the E4 Wristband Wearable Device
    PI: William Gormley, MD, MPH, MBA
  • Radiographic Analysis of Image-Guidance Technology to Improve Accuracy and Reduce Iatrogenic Hemorrhage Associated with Ventriculostomy
    PI: William Gormley, MD, MPH, MBA
  • Image and Function Guided Surgery of Brain Lesions
    PI: Alexandra Golby, MD
  • Brain Basis of Memory Studied by fMRI and Intracranial EEG
    PI: Alexandra Golby, MD
  • Digital Phenotyping of the Neurosurgical Patient: Towards More Effective Post-Operative Care – A Pilot Study
    PI: Timothy R. Smith, MD, PhD, MPH
  • Outcomes in Patients Undergoing Spine Surgery
    PI: Michael Groff, MD
  • Glioma and Pregnancy
    PI: Elizabeth Claus, MD, PhD
  • Biomarkers of Traumatic Brain Injury
    PI: William Gormley, MD, MPH, MBA
  • Intraoperative Stereotactic Molecular Imaging of Brain Tumor Margins
    PI: Alexandra Golby, MD
  • Incidence of C2 Dysesthesia After C1 Lateral Mass Screws: Comparison Between Techniques of C2 Nerve Sectioning and C2 Nerve Preservation
    PI: Michael Groff, MD
  • Retrospective Review of Patients Undergoing Arthroplasty vs ACDF
    PI: John Chi, MD, MPH
  • GWAS Database for Aneurysms
    PI: Rose Du, MD, PhD
  • Nanoscale Imaging of Neuromuscular Diseases
    PI: E. Antonio Chiocca, MD, PhD
  • Retrospective Review of Transitional Care from Hospital to Discharge
    PI: William Gormley, MD, MPH, MBA
  • Management of CNS Disorders Using Functional and Stereotactic Neurosurgical Interventions: Identifying Differentiating Features and Predictors of Improved Outcomes, in order to Improve Quality of Care
    PI: G. Rees Cosgrove, MD
  • Retrospective Analysis of the Operative Management of Chronic Subdural Hematomas Following a Modified Technique for Introduction of a Subdural Catheter
    PI: John Chi, MD, MPH
  • Diagnosis and Management of Rare CNS Lesions: Identifying Differentiating Features and Predictors of Improved Outcomes, in order to Improve Quality of Care
    PI: Timothy R. Smith, MD, PhD, MPH
  • Genetic Epidemiology of Cerebral Aneurysms
    PI: Rose Du, MD, PhD
  • Clinical Implications of Pipeline Embolization of Paraclinoidal Aneurysms
    PI: M. Ali Aziz-Sultan, MD
  • The Impact of Medical School Research Funding on Career Choices
    PI: Timothy R. Smith, MD, PhD, MPH
  • Long-term Outcomes for Neurosurgical Patients with Intra-Cranial Neoplasms
    PI: Elizabeth Claus, MD, PhD
  • Database of Skull Based Surgery Outcomes
    PI: Linda Bi, MD, PhD
  • Degenerative Spine Disease – Characteristics, Treatments and Complications
    PI: John Chi, MD, MPH
  • Neurovascular Disease Study
    PI: Rose Du, MD, PhD
  • Spine Surgery Discharge Disposition
    PI: William Gormley, MD, MPH, MBA
  • Evaluation and Treatment of Neurosurgical Disorders
    PI: Alexandra Golby, MD
  • Craniectomy Associated Complications
    PI: William Gormley, MD, MPH, MBA
  • Dural AVF Study
    PI: Rose Du, MD, PhD
  • Medical Complications in Patients with Intracranial Hemorrhage Managed in the NICU
    PI: William Gormley, MD, MPH, MBA
  • Analyzing Semantic Differences in the Documented Clinical Histories of Patients Undergoing Different Methods of Spinal Surgical Intervention
    PI: Michael Groff, MD
  • Non-Invasive Collection of Physiologic Data Using a Novel Diffuse Optical Tomography Device for Measurement of Cerebral Oximetry in Intracranial Stroke: A Prospective, Non-Randomized, Single Center, Single Arm, Observational Physiologic Data Collection Trial
    PI: William Gormley, MD, MPH, MBA
  • Indocyanine Green Angiography Guidance in Cranial Neurosurgery
    PI: Linda Bi, MD, PhD
  • Patient-Reported Outcome Measure for Meningiomas
    PI: Timothy R. Smith, MD, PhD, MPH
  • Use of Diffusion Tensor Imaging in Interventional MRI Implantation of Deep Brain Stimulation Electrodes
    PI: G. Rees Cosgrove, MD
  • Efficacy of 68Ga-DOTATATE PET/CT in the Diagnosis of Ectopic ACTH Secreting Tumors After Failed Surgery for Cushings Disease
    PI: Edward Laws, MD

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