Neurosurgery Research Studies

The Department of Neurosurgery at Brigham and Women’s Hospital is a pioneer in neuroscience and is dedicated to the research of neurological disorders including tumor biology, aneurysms, stroke, epilepsy, and spinal disorders.

Below are our current research studies and clinical trials. Please note that not all of the studies are human subject trials. Only studies with coordinator contact information listed are open to enrollment or are expected to be open in the near future. We suggest patient’s reference clinicaltrials.gov for a more complete list of open clinical trials.

Brain Tumor Research
  • A Phase 1 A Phase I Study of Ad-RTS-hIL-12, an Inducible Adenoviral Vector Engineered to Express hIL-12 in the Presence of the Activator Ligand Veledimex in Subjects with Recurrent or Progressive Glioblastoma or Grade III Malignant Glioma
    PI: E. Antonio Chiocca, MD, PhD, Protocol Number: 14-339/ATI001-102
    Study Information
    Study Coordinator: Ajay Naik (asnaik@partners.org)
    Study status: Open
  • A Phase I Study of the Treatment of Recurrent Malignant Glioma with rQNestin34.5v.2, a Genetically Engineered HSV-1 Virus, and immunomodulation with Cyclophosphamide
    PI: E. Antonio Chiocca, MD, PhD
    Study Information
    Study Coordinator: Ajay Naik (asnaik@partners.org)
    Study status: Open
  • Intraoperative Stereotactic Molecular Imaging of Brain Tumor Margins
    PI: Alexandra Golby, MD
    Study Information: Pending
    Study Contact: Brooke Hancock (bhancock@partners.org)
  • MR Elastography of Skull Base Lesions
    PI: Srinivasan Mukundan, MD, PhD, Protocol Number: 2014P002630
    Study Coordinator: Douglas Lane (drlane@bwh.harvard.edu)
  • Phase I Study of Neoadjuvant GMCI plus Immune Checkpoint Inhibitor Combined with Standard of Care for Newly Diagnosed High-Grade Gliomas
    PI: E. Antonio Chiocca, MD, PhD
    Study Information: Pending
    Study Status: Not Yet Open
Spine Research
  • SCOUT: Spineology Clinical Outcomes Trial 
    PI: John Chi, MD, MPH, Protocol Number: 2014P002660
    Study Information
    Study Flyer
    Study Coordinator: Douglas Lane (drlane@bwh.harvard.edu)
  • Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
    PI: Yi Lu, MD, PhD, Protocol Number: 2016P000100
    Study Information
    Study Coordinator: Douglas Lane (drlane@bwh.harvard.edu)
    Study status: Open
  • The INSPIRE Study: Probable Benefit of the Neuro- Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
    PI: Yi Lu, MD, PhD
    Study Information 
    Study Coordinator: Douglas Lane (drlane@bwh.harvard.edu)
    Study status: Active; Not accruing
Research in Functional Disorders

ExAblate Transcranial MRgFUS of the Globus Pallidum for Treatment of Parkinson's Disease
PI: G. Rees Cosgrove, MD, Protocol Number: 2016P000233
Study information: Pending
Study Coordinator: Taylor Krozy (tkrozy@bwh.harvard.edu)
Study status: Closed to Enrollment

Cerebrovascular Research
  • Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study
    PI: M. Ali Aziz-Sultan, MD, Protocol Number: 2015P000641
    Study Information
    Study Coordinator: Taylor Krozy (tkrozy@bwh.harvard.edu)
    Study status: Closed to Enrollment
  • ENRICH (Early MiNimally-invasive Removal of ICH)
    PI: M Ali Aziz-Sultan, MD
    Study Information
    Study Coordinator: Taylor Krozy (tkrozy@partners.org)
    Study Status: Open
  • DEFUSE 3: Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3
    PI: Steven Feske, MD/ Aziz-Sultan, MD
    Study information
    Study Coordinator: Karen Li (KL15@mgh.harvard.edu)     
Additional Research
  • Gene Expression in Cerebral Aneurysms
    PI: Rose Du, MD, PhD, Protocol Number: 2010P000076
  • Phase Synchronization Analysis of Intracranial Pressure Dynamics
    PI: Joseph Madsen, MD, Protocol Number: 2004P000697
  • Survival Rate of Brain Tumor Patients
    PI: Rona Carroll, PhD, Protocol Number: 2007P000471
  • Investigation of Neuronal Activity in Patients with Epilepsy
    PI: Sydney Cash, MD, PhD, Protocol Number: 2007P000165
  • Characterization of Presenting and Post-Surgical Headache in Patients with Pituitary Tumor
    PI: Edward Laws, MD, Protocol Number: 2010P002711
  • Endocrine and Surgical Complications in Pure Endoscopic Endonasal Transsphenoidal Surgery
    PI: Edward Laws, MD, Protocol Number:2012P002547
  • A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects
    PI: Rees Cosgrove, MD, Protocol Number: 2013P001216
  • Biospecimen Integrity - Assessing Quality and Influence on-Omics-based A 
    PI: Bruce Kristal, PhD, Protocol Number: 2011P002467
  • Codman Neurovascular Enterprise Vascular Reconstruction Device and Delivery System
    PI: Kai Frerichs, MD, Protocol Number: 2007P001147
  • Use of the Neuroform Stent, a Humanitarian Use Device, for the Treatment of Wide-Necked Use of the Neuroform Stent, a Humanitarian Use Device for the Treatment of Wide-Necked Cerebral Aneurysms
    PI: Kai Frerichs, MD, Protocol Number: 2003P000350
  • An Open-Label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of SAGE-547 Injection as Adjunctive Therapy in the Treatment of Adults with Super-Refractory Status Epilepticus
    PI: Henrikas Vaitkevicius, MD, Protocol Number: 2014P000162
  • Retrospective Review of Diffusion Tensor Imaging for Skull Base and Sellar Lesions
    PI: Edward Laws, MD, Protocol Number: 2013P000158
  • Behavioral and MRI Studies in Healthy Subjects
    PI: Alexandra Golby, MD, Protocol Number: 2003P001687
  • Outcomes for Neurosurgical Patients
    PI: Elizabeth Claus, MD, PhD, Protocol Number: 2003P001953
  • Intraoperative Stereotactic Molecular Imaging of Brain Tumor Margins
    PI: Alexandra Golby, MD, Protocol Number: 2011P002387
  • Neurosurgery Service Patient Database
    PI: Rona Carroll, PhD, Protocol Number: 1999P002046
  • Risk Factors and Outcomes for Glioma (GLIOGENE International Case/Control Study)
    PI: Elizabeth Claus, MD, PhD, Protocol Number: 2010P000385
  • Computerized Cognitive Tests During EEG Monitoring for Seizure Localization
    PI: Joseph Madsen, MD, Protocol Number: 2001P001621
  • Retrospective Review of Patients undergoing arthroplasty vs ACDF
    PI: John Chi, MD, MPH, Protocol Number: 2013P001722
  • Retrospective analysis of the operative management of chronic subdural hematomas following a modified technique
    for introduction of a subdural catheter
    PI: John Chi, MD, MPH, Protocol Number: 2013P002048
  • Spinal Meningiomas: Surgical Strategies and Outcome
    PI: Michael Groff, MD, Protocol Number: 2013P000730
  • Vertebral Body Resection for Recurrent Tethered Cord Syndrome
    PI: John Chi, MD, MPH, Protocol Number: 2013P000804
  • Thoracic Spinal Cord Detethering for Progressive Post-Operative Myelopathy
    PI: John Chi, MD, MPH, Protocol Number: 2013P000998
  • The GLIOGENE (Glioma Genetics) Study
    PI: Elizabeth Claus, MD, PhD, Protocol Number: 2006P001787
  • Validation of a Positron Probe in Glioma Surgery
    PI: Alexandra Golby, MD, Protocol Number: 2012P001497
  • Outcome Study for Shunted Patients With Idiopathic Normal Pressure Hydrocephalus
    PI: Rona Carroll, PhD, Protocol Number: 2006P001830
  • Results of Instrumented Fusion as a Treatment for Vertebral Pyogenic Osteomyelitis, a Retrospective Analysis
    PI: Michael Groff, MD, Protocol Number: 2012P002612
  • Surgery for Tumors of the Spinal Cord and Spinal Column, a Long-Term Outcomes and Survival Analysis
    PI: John Chi, MD, MPH, Protocol Number: 2011P000506
  • Brain Tissue Bank and Cell Repository
    PI: Rona Carroll, PhD, Protocol Number: 2003P000655
  • Wingspan Stent System with Gateway PTA Balloon Catheter for the Treatment of Symptomatic Intracranial Atherosclerotic Disease for Humanitarian Use
    PI: Kai Frerichs, MD, Protocol Number: 2006P000401
  • Genetics of Intracranial Vessels
    PI: Rose Du, MD, PhD, Protocol Number: 2011P002910
  • Image and Function Guided Surgery of Brain Lesions
    PI: Alexandra Golby, MD, Protocol Number: 2002P001238
  • Real-Time Detection and Phase-Locking of Theta Frequency Cortical Activity with Phase Specific Stimulation for Memory Testing in Invasively Monitored Epilepsy Patients
    PI: Joseph Madsen, MD, Protocol Number: 2009P002484
  • An Exploratory Study of Matrix Metalloproteinase Presence in Brain Tissue of Autopsy Patients without Neurological Diseases
    PI: Edward Smith, MD, Protocol Number: 2013P001597
  • Nutrition Modulated Metabolism as a Disease Risk Factor (Breast Cancer Model)
    PI: Bruce Kristal, PhD, Protocol Number: 2005P001305
  • GWAS Database for Aneurysms
    PI: Rose Du, MD, PhD, Protocol Number: 2011P002073
  • Caloric Restriction Biomarkers Predict Type II Diabetes
    PI: Bruce Kristal, PhD, Protocol Number: 2005P001308
  • Metabolomics and Lipidomics Analysis of CHRON Samples and Controls
    PI: Bruce Kristal, PhD, Protocol Number: 2012P001282
  • Brain Basis of Memory Studied by fMRI and Intracranial EEG
    PI: Alexandra Golby, MD, Protocol Number: 2004P000700
  • Neural Stem Cells Target Gene Therapy to Brain Tumors
    PI: Rona Carroll, PhD, Protocol Number: 2003P001809
  • Evaluation and Treatment of Neurosurgical Disorders
    PI: Alexandra Golby, MD, Protocol Number: 2008P001024
  • An Exploratory Study of Matrix Metalloproteinase Levels in the Urine and Spinal Fluid of Patients with Intra-Cranial Neoplasms
    PI: Edward Smith, MD, Protocol Number: 2009P002752
  • Database of Skull Based Surgery Outcomes
    PI: Ian Dunn, MD, Protocol Number: 2014P000427
  • Longterm Outcomes for Neurosurgical Patients with Intra-Cranial Neoplasms
    PI: Elizabeth Claus, MD, PhD, Protocol Number: 2002P001740
  • Neurovascular Disease Study
    PI: Rose Du, MD, PhD, Protocol Number: 2006P001829
  • The Value of the Visit in the Weiner Center for Preoperative Evaluation
    PI: Donna Dello Iacono, PhD, NP, Protocol Number: 2014P000343
  • Validated Biomarkers for Primary Macronutrient
    PI: Bruce Kristal, PhD, Protocol Number: 2009P001651
  • The Role of Transarterial Embolization in Spinal Tumors
    PI: Kai Frerichs, MD, Protocol Number: 2012P000153
  • Craniectomy Associated Complications
    PI: William Gormley, MD, MPH, Protocol Number: 2010P001804
  • Genetic Epidemiology of Cerebral Aneurysms
    PI: Rose Du, MD, PhD, Protocol Number: 2010P000075
  • Medical Complications in Patients with Intracranial Hemorrhage Managed in the Neuroscience Intensive Care Unit (NICU)
    PI: William Gormley, MD, MPH, Protocol Number: 2009P002766
  • Exosome Diagnostics for Tumors 
    PI: William Curry, MD, Protocol Number: 2008P001540
  • Radiographic analysis of image-guidance technology to improve accuracy and reduce iatrogenic hemorrhage associated with ventriculostomy
    PI: William Gormley, MD, MPH, Protocol Number: 2017P000499
  • Outcomes in patients undergoing spine surgery
    PI: Michael Groff, MD, Protocol Number: 2016P002820
  • Analyzing semantic differences in the documented clinical histories of patients undergoing different methods of spinal surgical intervention
    PI: Michael Groff, MD, Protocol Number: 2016P001814
  • Dural AVF study
    PI: Rose Du, MD, PhD, Protocol Number: 2016P001790
  • Immune escape mechanisms in brain tumors
    PI: Sean Lawler, PhD, Protocol Number: 2016P001378
  • Spine surgery discharge disposition
    PI: William Gormley, MD, MPH, Protocol Number: 2016P001064
  • Incidence of C2 dysesthesia after C1 lateral mass screws: Comparison between techniques of C2 nerve sectioning and C2 nerve preservation
    PI: Michael Groff, MD, Protocol Number: 2016P000868
  • Prospective Multicenter Cohort Study Comparing Extent of Tumor Resection Between Microscopic Transsphenoidal Surgery and Fully Endoscopic Transsphenoidal Surgery for Nonfunctioning Pituitary Adenomas [Transsphenoidal Extent of Resection Study - TRANSSPHER Study]
    PI: Edward Laws, MD, Protocol Number: 2016P000474
  • The MicroVention Low-profile Visualized Intraluminal Support (LVIS) Device
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2016P000441
  • Biomarkers in stroke and intracerebral hemorrhage
    PI: Rose Du, MD, PhD, Protocol Number: 2016P000433
  • Degenerative spine disease - Characteristics, Treatments and Complications
    PI: John Chi, MD, MPH, Protocol Number: 2016P000322
  • The impact of medical school research funding on career choices
    PI: Timothy Smith, MD, PhD, MPH, Protocol Number: 2016P000135
  • Digital Phenotyping of the Neurosurgical Patient: Towards More Effective Post-operative Care - A Pilot Study
    PI: Timothy Smith, MD, PhD, MPH, Protocol Number: 2016P000095
  • Diagnosis and management of rare CNS lesions: identifying differentiating features and predictors of improved outcomes, in order to improve quality of care
    PI: Timothy Smith, MD, PhD, MPH, Protocol Number: 2015P002352
  • Carotid Endarterectomy with Primary Closure
    PI: Rose Du, MD, PhD, Protocol Number: 2015P002484
  • Stroke quality review
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2015P002344
  • Clinical implications of pipeline embolization of paraclinoidal aneurysms
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2015P002343
  • Stent Deployment fluoroscopic protocol in the treatment of cerebrovascular pathology
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2015P002266
  • Flat panel parenchymal blood volume imaging in vasospasm and delayed ischemic neurologic deficit after aneurysmal subarachnoid hemorrhage
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2015P002104
  • Retrospective review of transitional care from hospital to discharge
    PI: William Gormley, MD, MPH, Protocol Number: 2015P001856
  • Biomarkers of Traumatic Brain Injury
    PI: William Gormley, MD, MPH, Protocol Number: 2015P001080
  • Three-dimensional angiography for intraoperative neuronavigatin during intracranial tumor resection: A technical note and case series
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2015P000505
  • Retrospective Review of Imaging Characteristics of Patients with Dural Arteriovenous Fistulas
    PI: Mohammad Aziz-Sultan, MD, Protocol Number: 2015P000296
  • Optical Coherence Tomography: Evaluation of the Retinal thickness and Correlation with Clinical Outcomes after Transsphenoidal Surgery
    PI: Edward Laws, MD, Protocol Number: 2014P002277
  • The Fate of the Pituitary Gland after Endoscopic Transsphenoidal Surgery
    PI: Edward Laws, MD, Protocol Number: 2014P002276
  • Identification of New Treatments and Biomarkers for Neonatal H-I Encephalopathy
    PI: Xin Wang, Protocol Number: 2014P000524
  • Database of skull based surgery outcomes
    PI: Ian Dunn, MD, Protocol Number: 2014P000427

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