Department of Pathology

About Our Research

The research laboratories of the Department encompass a wide variety of areas and emphasize a modern, multi-disciplinary approach to pathophysiology and mechanisms of disease. Selected examples of current activities in the areas of emphasis in the basic research groups of the Department of Pathology at Brigham and Women's Hospital are:

Cardiac Pathology

Research topics include: Cadiovascular dysfunction and cardiac device malfunction

Faculty

Richard Mitchell, MD, PhD
Vice Chair, Education, BWH
Professor of Pathology, HMS
Research Interests: transplantation pathology, cardiac and vascular pathology, immune-vessels

Robert F. Padera, Jr, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Frederick Schoen, MD, PhD
Executive Vice Chair, Pathology, BWH
Professor of Pathology, HMS
Research Interests: Host-biomaterial interactions, clinicopathologic correlations in heart valve.

Diseases of the Female Reproductive System

Research topics include: cervical and vulvular diseases, ovarian cancer and fallopian tubes, uterine leiomyoma, Endometrial Disease Research, and genetics of endometrial cancer

Faculty

Chris Crum, MD
Vice Chair, Women’s and Perinatal Pathology, BWH
Professor of Pathology, HMS
Research Interests: Cell of origin and its relevance to prevention or early detection in gynecologic.

Daniela Dinulescu, PhD
Scientist, BWH
Assistant Professor of Pathology, HMS
Research Interests: Cancer biology, malignancies of the gonads and reproductive tract

Michelle S. Hirsh MD, PhD
Chief, GU Pathology, BWH
Associate Professor of Pathology, HMS

George Mutter, MD
Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: carcinogenesis, endometrial cancer, gynecologic cancer, biomarkers

Marisa R. Nucci, MD
Pathologist, BWH
Associate Professor of Pathology, HMS

Bradley J. Quade, MD, PhD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Mesenchymal enoplasia of the female genital tract

Genetic Basis of Inherited Disorders

Research topics include: genetic hearing loss, and structural genomic variation, chromosomal arnormalities in cancer

Faculty 

Paola S. Dal Cin, PhD
Associate Cytogeneticist, BWH
Professor of Pathology, HMS

Anne Giersch, PhD
Associate Cytogeneticist, BWH
Assistant Professor of Pathology, HMS
Research Interests: The genetics of hearing, deafness, and age related hearing loss

Azra H. Ligon, PhD
Director, Clinical Cytogenetics, BWH
Associate Professor of Pathology, HMS

Cythia Morton, PhD
Director, Cytogenetics Research, BWH
Professor of Genetics and Pathology, BWH
Research Interests: Hereditary Deafness, Uterine Leiomyomata, Developmental Disorders

Heidi L. Rehm, PhD
Associate Molecular Geneticist, BWH
Associate Professor of Pathology, HMS
Research Interests: genomic medicine; molecular diagnostic test development; hearing loss

Immunology

Research topics include: Cellular interactions in immune responses, immunology of vascular endothelium, cytokines, lymphocyte activation and tolerance, targeted disruption of lymphocyte molecules, autoimmunity, and antigen presentation.

Faculty

Lynn Bry, MD, PhD
Associate Professor, BWH
Associate Professor of Pathology, HMS
Research Interests: Metagenomics, Microbiome, Pathology Informatics, Clinical Microbiology

Nir Grabie, PhD
Scientist, BWH
Instructor in Pathology, HMS
Research Interests: Influence of regulatory lymphocytes outside the Immune- Syrtem

Bruce Horwitz, MD, PhD
Associate Professor, HMS
Research Interests: Regulation of Mucosal Immunity

Andrew H. Lichtman, MD, PhD
Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: Immunology, Vascular Biology, Cardiovascular Disease

Scott B. Lovitch, MD, PhD
Associate Pathologist, BWH
Instructor in Pathology, HMS  
Research Interests: Immunology, immunometabolism, costimulation, immunoregulation

Richard N. Mitchell, MD, PhD
Vice Chair, Education, BWH
Professor of Pathology, HMS
Research Interests: transplantation pathology, cardiac and vascular pathology, immune-vessels

Leslie Silberstein, MD
Vice Chair, Transfusion Medicine
Professor of Pathology, HMS
Research Interests: Cell Manipulation, Transfusion Medicine, Haematopoietic stem cells

Arlene H. Sharpe, M.D., Ph.D.
Senior Scientist, BWH 
Co-Director of HITI, HMS

Infections Disease

Research Interests: Role and function of innate-like T Cells (CD1d-restricted....more

Faculty 

Manfred Brigl, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: Role and function of innate-like T Cells (CD1d-restricted.

Georg K. Gerber, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: computational and systems biology, synthetic biology, microbiome

Andrew B. Onderdonk, PhD
Director, Microbiology, BWH
Professor of Pathology, HMS
Research Interests: Role of the human microbiome in health and disease.

Molecular Oncology

Research topics include: Molecular studies of onco-genes and tumor suppressor genes, analysis of chromosomal aberrations in cancer and benign disorders, control of DNA synthesis and the cell cycle, mechanisms of gene transcription, immunogenetics, receptor mediated control of cell differentiation, signal transduction, and molecular methods of disease diagnosis

Faculty

Jon C. Aster, MD, PhD
Chief, Hematopathology, BWH
Professor of Pathology, HMS
Research Interests: oncogenic role of Notch signaling in T-cell acute lymphoblastic leukemia (T-ALL) and other cancers

Jane E. Brock, MBBS, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS 

Li Chai, MD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Cancer, stem cells, genetics and epigenetic, translation

Deborah A. Dillon MD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

David M. Dorfman, MD, PhD
Director, Hematology, BWH
Associate Professor of Pathology, HMS

Jonathan A. Fletcher, MD
Cytogeneticist, BWH
Associate Professor, HMS
Research Interests: Tumor biology of sarcoma, mesothelioma and pediatric solid cancers

Christopher French, MD
Associate Pathologist, BWH
Associate Professor, HMS
Research Interests: Oncogenic mechanisms; NUT midline carcinoma; cytopathology

Keith Ligon, MD, PhD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Cancer, brain tumors, stem cell, clinical trials

Massimo F. Loda, MD
Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: The role of lipid metabolism in prostate cancer and on metabolic profiling.

Adrian Marino-Enriquez, PhD
Scientist, BWH
Instructor of Pathology, HMS
Research Interests: Sarcoma translational research including biology, nosology

Matthew Meryerson, PhD
Professor of Pathology, HMS
Research Interests: Cancer genomics, cancer biology and targeted therapies

Shiji Ogino, MD, PhD
Pathologist, BWH
Professor of Pathology, HMS
Research Interests: molecular pathological epidemiology

Sunita R. Setlur, PhD
Scientist, BWH
Instructor in Pathology, HMS

Lynette M. Sholl, MD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Sabina Signoretti, MD
Research Scientist, BWH
Associate Professor of Pathology, HMS
Research Interests: Genitourinary malignancies. Genitourinary tract development.

Amitabh Srivastava, MD
Associate Director, Surgical Pathology, BWH
Associate Professor of Pathology, HMS

Sheng Xiao, MD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Giorgia Zadra, PhD
Instructor of Pathology, HMS
Research Interests: prostate cancer metabolism

Molecular Pathology

Faculty

Martha L. Bulyk, PhD
Associate Professor of Medicine and Pathology, HMS
Research Interests: transcription factors, TF-DNA interactions, transcriptional enhancers

Sacha Uljon, MD
Associate Pathologist, BWH
Instructor of Pathology, HMS

Pulmonary Pathobiology

Research topics include: Mechanisms of inhalant-induced lung injury, the biology of alveolar macrophages, pathogenesis of mesothelioma and the molecular basis of lung development, including neuroendocrine differentiation.

Faculty

Lester Kobzik, MD
Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: Lung host defenses against inhaled pathogens, pollutants, allergens

Lucian R. Chirieac, MD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS

Neal I. Lindeman, MD
Director, Molecular Genetics, BWH
Associate Professor of Pathology, HMS

Scott J. Rodig, MD, PhD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS

Neuropathology

Research topics include: Oncogenesis of glial tumors, developmental neurobiology, and neurodegenerative diseases.

Faculty 

Mel B. Feany, MD, PhD
Neuropathologist, BWH
Professor of Pathology, HMS
Research Interests: Modeled human neurological diseases, including Alzheimer’s Disease

Jeffrey Golden, MD
Chairman of Pathology, BWH
Ramzi Cotran Professor of Pathology, HMS
Research Interests: Developmental Neurobiology, epilepsy, malformations of

Ginam Cho, PhD
Scientist, BWH
Instructor of Pathology, HMS
Research Interests: forebrain development, ER-mitochondria contact

Keith Ligon, MD, PhD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Cancer, brain tumors, stem cell, clinical trials

Sandro Santagata, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Skin Disease

Research topics include: skin lymphoma, melanoma, and sweat gland tumor

Faculty

George F. Murphy, MD
Chair, Dermatopathology, BWH
Professor of Pathology, HMS
Research Interests: ytotoxicity, stem cells, biomarkers

Scott R. Granter, MD
Associate Pathologist, BWH
Associate Professor of Pathology, HMS

John W. Hanna, MD, PhD
Associate Pathologist, BWH
Instructor in Pathology, HMS
Research Interests: protein degradation, ubiquitin-proteasome system.

Christine Guo Lian, MD
Associate Pathologist, BWH
Instructor of Pathology, HMS
Research Interests: Epigenetic regulations of melanoma and skin diseases

Surgical Pathology

Research topics include: Gastrointestinal stromal tumor, inflammatory bowel disease, sarcoma, liposarcomas, and preneoplastic gastrointestinal conditions

Faculty:

Tony Agoston, MD, PhD
Associate Pathologist, BWH
Instructor in Pathology, HMS

Justine A. Barletta, MD
Chief, Endocrinology, BWH
Assistant Professor of Pathology, HMS

Christopher D. M. Fletcher, MD
Vice Chair, Surgical Pathology, BWH
Professor of Pathology, HMS

Jonathan A. Fletcher, MD
Cytogeneticist, BWH
Associate Pathologist, HMS
Research Interests: Tumor biology of sarcoma, mesothelioma and pediatric solid cancers.

Jason L. Hornick, MD, PhD
Director, Surgical Pathology, BWH
Associate Professor of Pathology, HMS

Alarice C-Y. Lowe, MD
Associate Pathologist, BWH
Instructor in Pathology, HM

Elizabeth A. Morgan, MD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Robert D. Odze, MD
Chief, GI Pathology, BWH
Professor of Pathology, HMS

Matthew D. Stachler, MD, PhD
Associate Pathologist, BWH
Instructor in Pathology, HMS
Research Interests: Gastrointestinal cancer, Esophageal adenocarcinoma, Barrett's esophagus

Astrid Weins, MD, PhD
Associate Pathologist, BWH
Instructor in Pathology, HMS

Vascular Biology

Research topics include: Leukocyte-endothelial interactions, molecular basis of endothelial gene expression and role of hemodynamic factors, targeted disruption of endothelial adhesion molecules, molecular mechanism of atherosclerosis.

Faculty:

Michael A. Gimbrone, Jr, MD
Director, Center of Excellence in Vascular Biology, BWH
Professor of Pathology, HMS
Research Interests: Vascular (patho)biology; endothelium; atherogenesis.

Guillermo Garcia-Cardena, PhD
Scientist, BWH
Associate Professor of Pathology, HMS
Research Interests: Molecular, bioengineering, and bioinformatics approaches to understand

Francis William Luscinskas, PhD
Associate Director, Vascular Biology, BWH
Professor of Pathology, HMS
Research Interests: Vascular Cell Biology; Immunology; Leukocyte recruitment.

Tanya Mayadas-Norton, PhD
Scientist, BWH
Professor of Pathology, HMS
Research Interests: Innate immune mechanisms of tissue injury; leukocyte recruitment

Francisco Cullere-Luengo, PhD
Scientist, BWH
Instructor in Pathology, HMS 

David S. Milestone, MD, PhD
Scientist, BWH
Assistant Professor of Pathology, HMS
Research Interests: developmental vascular biology