The rapidly expanding field of skeletal biology promises to yield major treatment advances in many areas of orthopedic surgery over the next few decades. Our basic, clinical, and translational research concerns skeletal repair, skeletal tissue engineering, and normal and abnormal bone metabolism.
The Brigham and Women’s Hospital Skeletal Biology Research Laboratory has particular interest in the study of skeletal aging, metabolic bone disease, skeletal tissue engineering, and osteoinductive materials. The scientific approaches focus on translational research, i.e., the identification of clinical problems, testing of hypotheses in relevant experimental models, and application to patient care. Innovative 3-dimensional culture devices serve as a platform technology for many of the osseous reconstructive and pathophysiological programs of research ongoing in the Laboratory. One of our major research activities concerns the mechanisms by which osteoinductive materials, like demineralized bone matrix, induce the differentiation of chondrocytes from skin-derived fibroblasts and the potential to apply this phenomenon to various clinical applications.
The Laboratory is the hub for several multidisciplinary, cross-departmental programs, especially between members of the BWH Skeletal Health and Osteoporosis Center, led by Meryl LeBoff, M.D., and clinical members of the Department of Orthopedic Surgery and the Division of Rheumatology. With multidisciplinary collaborators, the Laboratory seeks to translate new basic and clinical research into a platform for skeletal health and orthopedic care.
SELECTED RECENT REFERENCES:
Rosen C, Glowacki J, Bilzekian JP (eds) The Aging Skeleton, Academic Press, San Diego, CA, 1999.
LeBoff M, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal American women with acute femur fracture. J Amer Med Assoc 1999; 16:1505-1511.
Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem 2001;82:583-590.
Mizuno S, Tateishi T, Ushida T, Glowacki J. Hydrostatic fluid pressure enhances matrix synthesis and accumulation by bovine chondrocytes in three-dimensional culture. J Cell Phys 2002;193:319-27.
Glowacki J, Hurwitz S, Thornhill TS, Kelley M, LeBoff ML. Osteoporosis and vitamin D deficiency among postmenopausal osteoarthritic women undergoing total hip arthroplasty. J Bone Joint Surg. 2003; 85A: 2371-2377.
Warden S, Zaleske DJ, Glowacki J. Fate of a chimeric joint construct in an ectopic site in SCID mice. Cell Transplantation 2004; 13:161-168.
Eid K, Thornhill TS, Glowacki J. Chondrocyte gene expression in osteoarthritis: Correlation with disease severity. J Orthop Res 2006;24:1062-8.
Glowacki J, Mizuno S. Collagen scaffolds for tissue engineering. Biopolymers. 89:338-344; 2008.
Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, LeBoff MS, Glowacki J. Age-related intrinsic changes in human marrow stromal cells and their differentiation to osteoblasts. Aging Cell. 2008 7:335-343.
Glowacki J, Harris M, Simon J, Wright J, Kolatkar N, Thornhill TS, LeBoff MS. Brigham fracture intervention team (B-FIT) initiatives for hospital patients with hip fractures: A paradigm shift. Intl J Endocrin. 2009.