Systemic Lupus Erythematosus

Systemic Lupus Associated T-cell Effects “SLATE”

We are conducting a longitudinal study (24 months) to understand the treatment of Lupus among those
who have been newly diagnosed with the disease. Participants must meet American College of
Rheumatology criteria for lupus and be diagnosed in the last 12 months without starting
immunosuppressive treatment. Participants will be asked to complete survey questionnaires and
provide blood samples over the course of 3-5 study visits. Parking or transportation vouchers may be
provided. Study visits can occur at Orthopedic and Arthritis Center (BWH Main Campus,) Faulkner
Hospital or at the Rheumatology clinic at 850 Boylston Street for convenience.

For more information about this study, please contact Gregory Keras gkeras@bwh.harvard.edu

Funded by: Lupus Research Alliance

 


 

CALM: Assessing Cardiovascular Risk among Patients with Systemic Lupus Erythematosus

Principal Investigator:  Elena M Massarotti, MD  and Karen H. Costenbader, MD, MPH   

Study Contact: Cameron Speyer (617-264-5907; cspeyer@bwh.harvard.edu

Study Summary: This is an observational research study examining cardiovascular risk factors over 6-8 months among patients who have been diagnosed with systemic lupus erythematosus. Participants will complete survey questionnaires, provide blood samples and have heart imaging over the course of up to 5 study visits.

Patient Criteria: Participants must have active lupus disease at time of consent and must not have any known cardiac disease affecting physical activity or have any heart-related symptoms present even at rest.

Visit Summary: Study visits will occur in the BWH Lupus Center and the BWH Shapiro Cardiovascular Center, at the BWH Main Campus.

Patient Remuneration: Participants will receive up to $200 for study participation and costs of transportation or parking will be covered.

 


 

Physical and Mental Health and Medication Use among Patients with Lupus

Principal Investigator: Candace Feldman, MD, MPH

Study Contact: Courtnie Phillip (617-732-6356; cphillip1@bwh.harvard.edu)

Funding Agency: Rheumatology Research Foundation

Study Summary: We are conducting a research study to understand changes in mental and physical health and medication use among patients with lupus over 6-8 months.

Patient Criteria: We are looking for participants who have been diagnosed with lupus and are currently taking a lupus medication.

Visit Summary: Participants will complete a total of 3 sets of surveys either online or at the time of your rheumatology appointment.

Patient Remuneration: Participants will receive either a parking or cafeteria voucher for each completed set of surveys.

 


 

ACE (Closed to Enrollment)

Principal Investigator: Elena M Massarotti, MD

Study Contact: Jung Lee (617-525-7654; jlee181@partners.org)

Funding Agency: Division of Allergy, Immunology, and Transplantation (DAIT) and the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)

Study Summary: We are doing this research study to find out if patients who have bene on Mycophenolate Mofetil (MMF) for 1 to 2 years and whose Systemic Lupus Erythematosus (SLE, lupus) is quiet can safely stop their MMF medication. Participants will be randomly assigned to one of two groups

  1. MMF continuation group will continue MMF at a set dose.
  2. MMF withdrawal group will be slowly tapered off their MMF over 3 months.

Patient Criteria: Adults who have been diagnosed with lupus but is not active. Participants must be taking MMF and have been taking MMF for 1-2 years.

Visit Summary: We will ask you to make 12 study visits over 60 weeks. The visits will consist of a physical exam, questionnaires, and blood and urine sample collection. The study drug (MMF) will be supplied to you during this study.

Patient Remuneration: Participants will receive payment in the form of a parking voucher to cover parking costs for each study visit.