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Endoscopic Weight Management Research

Clinical Trials

Brigham and Women’s Hospital currently offers several endoscopic weight loss and diabetes procedures that are under clinical investigation.

Endoscopic Sleeve Gastroplasty (MERIT Trial)
Ongoing (closed for recruitment)

EndoBarrier (STEP-1)
Endobarrier is an endoscopic device to treat diabetes and obesity. A liner is endoscopically placed in the first part of your small bowel for 12 months. This procedure is done through the mouth without any incisions.

If you meet the following criteria, you may qualify for the trial:

  • Age 30-65
  • BMI 30-50 kg/m2
  • Have type 2 diabetes
  • Hemoglobin A1c 8-10%
  • Have been on at least 3 diabetes medications
  • Not on insulin

If you are interested in participating in the trial, please contact Michele Ryan at mryan@bwh.harvard.edu.

Duodenal Mucosal Resurfacing (Safety & Effectiveness of DMR Using the Revita)
The DMR system is an endoscopic device that treats diabetes with less of an effect on weight. The procedure involves heat resurfacing of the duodenum (first part of the small bowel) and does not require an implant.

If you meet the following criteria, you may qualify for the trial:

  • Age 28-65
  • BMI 28-40 kg/m2
  • Have type 2 diabetes
  • Hemoglobin A1c 7.5-9.5%
  • Have been on at least 2 diabetes medications
  • Not on insulin or other injectable diabetes medications

If you are interested in participating in the trial, please contact Michele Ryan at mryan@bwh.harvard.edu.

Publications

Here are some of the selected publications from our group.

Endoscopic Weight Management Publications

Overview of Bariatric Endoscopy

Jirapinyo P, Thompson CC. How to Incorporate Bariatric Training Into Your Fellowship Program. Gastroenterology. 2019 Jul;157(1):9-13. PubMed PMID: 31150606.

Jirapinyo P, Thompson CC. Training in Bariatric and Metabolic Endoscopic Therapies. Clin Endosc. 2018 Sep;51(5):430-438. PubMed PMID: 30301319; PubMed Central PMCID: PMC6182289.

Thompson CC, editor. Bariatric Endoscopy, Second Edition. New York: Springer Science+Business Media; forthcoming 2018.

Ryou M, McQuaid KR, Thompson CC, Edmundowicz S, Mergener K; ASGE EndoVators Task Force. ASGE EndoVators Summit: Defining the Role and Value of Endoscopic Therapies in Obesity Management. Obes Surg. 2018 Jan;28(1):3-14. PubMed PMID: 29139029.

ASGE EndoVators Task Force, Ryou M, McQuaid KR, Thompson CC, Edmundowicz S, Mergener K, Dayyeh BA, Apovian C, Burke C, Chand B, Chandraker A, Deas T, Dietz W, Dunkin B, Ernest O, Faigel D, Garber S, Hamdy O, Kaplan L, Kumar N, Kushner R, Larsen MC, Lerner H, Littenberg G, Mantzoros C, Mattar S, Moore R, Rinella M, Rothstein R, Schillinger D, Spring B, Sullivan S, Tice J, Vargo J, Wilson E, Woods K, Zundel N. ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management. Gastrointest Endosc. 2017 Nov;86(5):757-767. PubMed PMID: 29031371.

Jirapinyo P, Thompson CC. Endoscopic Bariatric and Metabolic Therapy: Surgical Analogues and Mechanisms of Action. Clin Gastroenterol Hepatol. 2017 May;15(5):619-630. Review. PubMed PMID: 27989851.

Sullivan S, Edmundowicz SA, Thompson CC. Endoscopic Bariatric and Metabolic Therapies: New and Emerging Technologies. Gastroenterology. 2017 May;152(7):1791-1801. PubMed PMID: 28192103.

Abu Dayyeh BK, Edmundowicz S, Thompson CC. Clinical Practice Update: Expert Review on Endoscopic Bariatric Therapies. Gastroenterology. 2017 Mar;152(4):716-729. Review. PubMed PMID: 28147221.

ASGE Bariatric Endoscopy Task Force, Sullivan S, Kumar N, Edmundowicz SA, Abu Dayyeh BK, Jonnalagadda SS, Larsen M, Thompson CC. ASGE position statement on endoscopic bariatric therapies in clinical practice. Gastrointest Endosc. 2015 Nov;82(5):767-72. PubMed PMID: 26282949.

ASGE Bariatric Endoscopy Task Force and ASGE Technology Committee, Abu Dayyeh BK, Kumar N, Edmundowicz SA, Jonnalagadda S, Larsen M, Sullivan S, Thompson CC, Banerjee S. ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies. Gastrointest Endosc. 2015 Sep;82(3):425-438. PubMed PMID: 26232362.

ASGE Bariatric Endoscopy Task Force; ASGE Technology Committee, Abu Dayyeh BK, Edmundowicz SA, Jonnalagadda S, Kumar N, Larsen M, Sullivan S, Thompson CC, Banerjee S. Endoscopic bariatric therapies. Gastrointest Endosc. 2015 May;81(5):1073-86. PubMed PMID: 25828245

Ginsberg GG, Chand B, Cote GA, Dallal RM, Edmundowicz SA, Nguyen NT, Pryor A, Thompson CC. ASGE/ASMBS Task Force on Endoscopic Bariatric Therapy. A pathway to endoscopic bariatric therapies. Gastrointest Endosc. 2011 Nov;74(5):943-53. PubMed PMID: 22032311.

Abu Dayyeh BK, Thompson CC. Obesity and bariatrics for the endoscopist: new techniques. Therap Adv Gastroenterol. 2011 Nov;4(6):433-42. PubMed PMID: 22043233; PubMed Central PMCID: PMC3187679.

Ryou M, Ryan MB, Thompson CC. Current status of endoluminal bariatric procedures for primary and revision indications. Gastrointest Endosc Clin N Am. 2011 Apr;21(2):315-33. Review. PubMed PMID: 21569983. PMCID: PMC3460649.

Thompson CC. Endoscopic therapy of obesity: a new paradigm in bariatric care. Gastrointest Endosc. 2010 Sep;72(3):505-7. PubMed PMID: 20801286.

Obstein KL, Thompson CC. Endoscopy after bariatric surgery (with videos). Gastrointest Endosc. 2009 Dec;70(6):1161-6. Review. PubMed PMID: 19647249.

Blackburn GL, Hutter MM, Harvey AM, Apovian CM, Boulton HR, Cummings S, Fallon JA, Greenberg I, Jiser ME, Jones DB, Jones SB, Kaplan LM, Kelly JJ, Kruger RS Jr, Lautz DB, Lenders CM, Lonigro R, Luce H, McNamara A, Mulligan AT, Paasche-Orlow MK, Perna FM, Pratt JS, Riley SM Jr, Robinson MK, Romanelli JR, Saltzman E, Schumann R, Shikora SA, Snow RL, Sogg S, Sullivan MA, Tarnoff M, Thompson CC, Wee CC, Ridley N, Auerbach J, Hu FB, Kirle L, Buckley RB, Annas CL. Expert panel on weight loss surgery: executive report update. Obesity (Silver Spring). 2009 May;17(5):842-62. Review. PubMed PMID: 19396063.

Ellsmere JC, Thompson CC, Brugge WR, Chuttani R, J Desilets D, Rattner DW, E Tarnoff M, Kaplan LM. Endoscopic interventions for weight loss surgery. Obesity (Silver Spring). 2009 May;17(5):929-33. Review. PubMed PMID: 19396074.

Endoscopic Gastric Plication (Distal POSE)

Jirapinyo P, Thompson CC. Endoscopic Gastric Body Plication for the Treatment of Obesity: Technical Success and Safety of a Novel Technique. Gastrointestinal Endoscopy. 2020 Jan 27. [Epub ahead of print]. PMID: 32001332.

Jirapinyo P, Thompson CC. Gastric plications for weight loss: distal primary obesity surgery endoluminal through a belt-and-suspenders approach. VideoGIE. 2018 Sep 6;3(10):296-300. PubMed PMID: 30276347; PubMed Central PMCID: PMC6162872.

Sullivan S, Swain JM, Woodman G, Antonetti M, De La Cruz-Muñoz N, Jonnalagadda SS, Ujiki M, Ikramuddin S, Ponce J, Ryou M, Reynoso J, Chhabra R, Sorenson GB, Clarkston WK, Edmundowicz SA, Eagon JC, Mullady DK, Leslie D, Lavin TE, Thompson CC. Randomized sham-controlled trial evaluating efficacy and safety of endoscopic gastric plication for primary obesity: The ESSENTIAL trial. Obesity (Silver Spring). 2017 Feb;25(2):294-301. PubMed PMID: 28000425.

Endoscopic Sleeve Gastroplasty (ESG)

Singh S, Hourneaux de Moura DT, Khan A, Bilal M, Ryan MB, Thompson CC. Safety and efficacy of endoscopic sleeve gastroplasty worldwide for treatment of obesity: a systematic review and meta-analysis. Surg Obes Relat Dis. 2020 Feb;16(2):340-351. PMID: 31932205.

Hedjoudje A, Abu Dayyeh BK, Cheskin LJ, Adam A, Neto MG, Badurdeen D, Morales JG, Sartoretto A, Nava GL, Vargas E, Sui Z, Fayad L, Farha J, Khashab MA, Kalloo AN, Alqahtani AR, Thompson CC, Kumbhari V. Efficacy and Safety of Endoscopic Sleeve Gastroplasty: A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol. 2019 Aug 20. [Epub ahead of print]. PMID: 31442601.

Barrichello S Jr, Hourneaux de Moura DT, Hourneaux de Moura EG, Jirapinyo P, Hoff AC, Fernandes Fittipaldi JR, Baretta G, Felício Lima JH, Usuy EN, Salles L, Ramos FM, Matz F, Galvao Dos Passos Neto M, Thompson CC. Endoscopic sleeve gastroplasty in the management of overweight and obesity: an international multicenter study. Gastrointest Endosc. 2019 Jun 19. pii: S0016-5107(19)31958-3. doi: 10.1016/j.gie.2019.06.013. [Epub ahead of print] PubMed PMID: 31228432.

de Moura DTH, de Moura EGH, Thompson CC. Endoscopic sleeve gastroplasty: From whence we came and where we are going. World J Gastrointest Endosc. 2019 May 16;11(5):322-328. PubMed PMID: 31205593; PubMed Central PMCID: PMC6556490.

Kumar N, Abu Dayyeh BK, Lopez-Nava Breviere G, Galvao Neto MP, Sahdala NP, Shaikh SN, Hawes RH, Gostout CJ, Goenka MK, Orillac JR, Alvarado A, Jirapinyo P, Zundel N, Thompson CC. Endoscopic sutured gastroplasty: procedure evolution from first-in-man cases through current technique. Surg Endosc. 2018 Apr;32(4):2159-2164. PubMed PMID: 29075966.

Brethauer SA, Chand B, Schauer PR, Thompson CC. Transoral gastric volume reduction as intervention for weight management: 12-month follow-up of TRIM trial. Surg Obes Relat Dis. 2012 May-Jun;8(3):296-303. PubMed PMID: 22178565.

Brethauer SA, Chand B, Schauer PR, Thompson CC. Transoral gastric volume reduction for weight management technique and feasibility in 18 patients. Surg Obes Relat Dis. 2010 Nov-Dec;6(6):689-94. PubMed PMID: 20947451.

Intragastric Balloon

Jirapinyo P, Cenaj O, Ryou M, Thompson CC. Intragastric Balloons: An Emerging Therapy for NASH and Fibrosis? American Journal of Gastroenterology Case Reports Journal. 2019;6(7):e00142. PMID:31620539.

Barrichello S, de Moura DTH, Hoff AC, Veinert A, Thompson CC. Acute pancreatitis due to intragastric balloon hyperinflation (with video). Gastrointest Endosc. 2019 Dec 19. [Epub ahead of print]. PMID: 31866316.

Kumar N, Sullivan S, Thompson CC. The role of endoscopic therapy in obesity management: intragastric balloons and aspiration therapy. Diabetes Metab Syndr Obes. 2017 Jul 6;10:311-316. Review. PubMed PMID: 28740414; PubMed Central PMCID: PMC5505535.

Storm AC, Lakdawala NK, Thompson CC. Intragastric balloon for management of morbid obesity in a candidate for heart transplantation. J Heart Lung Transplant. 2017 Jul;36(7):820-821 PubMed PMID: 28479033.

Popov VB, Ou A, Schulman AR, Thompson CC. The Impact of Intragastric Balloons on Obesity-Related Co-Morbidities: A Systematic Review and Meta-Analysis. Am J Gastroenterol. 2017 Mar;112(3):429-439. Review. PubMed PMID: 28117361.

Kumar N, Bazerbachi F, Rustagi T, McCarty TR, Thompson CC, Galvao Neto MP, Zundel N, Wilson EB, Gostout CJ, Abu Dayyeh BK. The Influence of the Orbera Intragastric Balloon Filling Volumes on Weight Loss, Tolerability, and Adverse Events: a Systematic Review and Meta-Analysis. Obes Surg. Sep;27(9):2272-2278. PubMed PMID: 28285471.

Popov VB, Thompson CC, Kumar N, Ciarleglio MM, Deng Y, Laine L. Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2016 Sep;61(9):2477-87.

Moura D, Oliveira J, De Moura EG, Bernardo W, Galvão Neto M, Campos J, Popov VB, Thompson C. Effectiveness of intragastric balloon for obesity: A systematic review and meta-analysis based on randomized control trials. Surg Obes Relat Dis. 2016 Feb;12(2):420-9. Review. PubMed PMID: 26968503.

Aspiration Therapy

Jirapinyo P, de Moura DTH, Horton LC, Thompson CC. Effect of Aspiration Therapy on Obesity-Related Comorbidities: Systematic Review and Meta-Analysis. Clinical Endoscopy. 2020 Feb 28. [Epub ahead of print]. PMID:32106362.

Jirapinyo P, Sullivan S, Thompson CC. Incremental Cost-Effectiveness of Aspiration Therapy vs Bariatric Surgery and No Treatment for Morbid Obesity. Am J Gastroenterol. 2020 Mar;115(3):481-482. PMID:31996557.

Thompson CC, Abu Dayyeh BK, Kushnir V, Kushner RF, Jirapinyo P, Schorr AB, Aronne LJ, Amaro A, Jaffe DL, Schulman AR, Early D, Stein AC, Sharaiha R, Edmundowicz SA, Bohning JM, Jensen MD, Shukla AP, Apovian C, Kim DW, Tran D, Zarrinpar A, Ryan MB, Young M, Lowe A, Haas M, Goldsmith H, McCrea J, Sullivan S. Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial. Surg Obes Relat Dis. 2019 May 2. pii:S1550-7289(18)31266-8. doi: 10.1016/j.soard.2019.04.026. [Epub ahead of print] PubMed PMID: 31302000.

Kumar N, Sullivan S, Thompson CC. The role of endoscopic therapy in obesity management: intragastric balloons and aspiration therapy. Diabetes Metab Syndr Obes. 2017 Jul 6;10:311-316. Review. PubMed PMID: 28740414; PubMed Central PMCID: PMC5505535.

Thompson CC, Abu Dayyeh BK, Kushner R, Sullivan S, Schorr AB, Amaro A, Apovian CM, Fullum T, Zarrinpar A, Jensen MD, Stein AC, Edmundowicz S, Kahaleh M, Ryou M, Bohning JM, Ginsberg G, Huang C, Tran DD, Glaser JP, Martin JA, Jaffe DL, Farraye FA, Ho SB, Kumar N, Harakal D, Young M, Thomas CE, Shukla AP, Ryan MB, Haas M, Goldsmith H, McCrea J, Aronne LJ. Percutaneous Gastrostomy Device for the Treatment of Class II and Class III Obesity: Results of a Randomized Controlled Trial. Am J Gastroenterol. 2017 Mar;112(3):447-457. PubMed PMID: 27922026.

TORe

Jirapinyo P, de Moura DTH, Thompson CC. Endoscopic Submucosal Dissection with Suturing for the Treatment of Weight Regain after Gastric Bypass: Outcomes and Comparison to Traditional Transoral Outlet Reduction (TORe). Gastrointestinal Endoscopy. 2020 Jan 30. [Epub ahead of print]. PMID: 32007520.

Jirapinyo P, Kumar N, AlSamman MA, Thompson CC. Five Year Outcomes Following Transoral Outlet Reduction (TORe) Show Durable Treatment of Weight Regain after Roux-en-Y Gastric Bypass. Gastrointestinal Endoscopy. 2019 Dec 6. [Epub ahead of print]. PMID: 31816315.

de Moura DTH, Jirapinyo P, Thompson CC. Modified-ESD Plus APC and Suturing for Treatment of Weight Regain After Gastric Bypass. Obes Surg. 2019 Jun;29(6):2001-2002. PubMed PMID: 30937873.

Jirapinyo P, Kröner PT, Thompson CC. Purse-string transoral outlet reduction (TORe) is effective at inducing weight loss and improvement in metabolic comorbidities after Roux-en-Y gastric bypass. Endoscopy. 2018 Apr;50(4):371-377. PubMed PMID: 29253919.

Schulman AR, Kumar N, Thompson CC. Transoral outlet reduction: a comparison of pursestring to interrupted stitch technique. Gastrointest Endosc. 2018 May;87(5):1222-1228. PubMed PMID: 29108984.

Jirapinyo P, Dayyeh BK, Thompson CC. Gastrojejunal anastomotic reduction for weight regain in roux-en-y gastric bypass patients: physiological, behavioral, and anatomical effects of endoscopic suturing and sclerotherapy. Surg Obes Relat Dis. 2016 Dec;12(10):1810-1816. PubMed PMID: 27998543; PubMed Central PMCID: PMC5178872.

Kumar N, Thompson CC. Transoral outlet reduction for therapy of weight regain after gastric bypass: long-term follow-up. Gastrointest Endosc. 2016 Apr;83(4):776-9. PubMed PMID: 26344204.

Kumar N, Thompson CC. Comparison of a superficial suturing device with a full-thickness suturing device for transoral outlet reduction (with videos). Gastrointest Endosc. 2014 Jun;79(6):984-9. PubMed PMID: 24721521.

Jirapinyo P, Slattery J, Ryan MB, Abu Dayyeh BK, Lautz DB, Thompson CC. Evaluation of an endoscopic suturing device for transoral outlet reduction in patients with weight regain following Roux-en-Y gastric bypass. Endoscopy. 2013; 45: 532–536.

Thompson CC, Chand B, Chen YK, Demarco DC, Miller L, Schweitzer M, Rothstein RI, Lautz DB, Slattery J, Ryan MB, Brethauer S, Schauer P, Mitchell MC, Starpoli A, Haber GB, Catalano MF, Edmundowicz S, Fagnant AM, Kaplan LM, Roslin MS. Endoscopic Suturing for Transoral Outlet Reduction Increases Weight Loss Following Roux-en-Y Gastric Bypass Surgery. Gastroenterology. 2013 Jul;145(1):129-137.e3. PubMed PMID: 23567348.

Thompson CC, Slattery J, Bundga ME, Lautz DB. Peroral endoscopic reduction of dilated gastrojejunal anastomosis after Roux-en-Y gastric bypass: a possible new option for patients with weight regain. Surg Endosc. 2006 Nov;20(11):1744-8. PubMed PMID: 17024527.

ROSE

Thompson CC, Jacobsen GR, Schroder GL, Horgan S. Stoma size critical to 12-month outcomes in endoscopic suturing for gastric bypass repair. Surg Obes Relat Dis. 2012 May-Jun;8(3):282-7. PubMed PMID: 21640665.

Horgan S, Jacobsen G, Weiss GD, Oldham JS Jr, Denk PM, Borao F, Gorcey S, Watkins B, Mobley J, Thompson K, Spivack A, Voellinger D, Thompson CC, Swanstrom L, Shah P, Haber G, Brengman M, Schroder G. Incisionless revision of post-Roux-en-Y bypass stomal and pouch dilation: multicenter registry results. Surg Obes Relat Dis. 2010 May-Jun;6(3):290-5. PubMed PMID: 20510293.

Mullady DK, Lautz DB, Thompson CC. Treatment of weight regain after gastric bypass surgery when using a new endoscopic platform: initial experience and early outcomes (with video). Gastrointest Endosc. 2009 Sep;70(3):440-4. PubMed PMID: 19555944.

Ryou MK, Mullady DK, Lautz DB, Thompson CC. Pilot study evaluating technical feasibility and early outcomes of second-generation endosurgical platform for treatment of weight regain after gastric bypass surgery. Surg Obes Relat Dis. 2009 Jul-Aug;5(4):450-4. PubMed PMID: 19632645.

Herron DM, Birkett DH, Thompson CC, Bessler M, Swanström LL. Gastric bypass pouch and stoma reduction using a transoral endoscopic anchor placement system: a feasibility study. Surg Endosc. 2008 Apr;22(4):1093-9. PubMed PMID: 18027049.

APC

Jirapinyo P, de Moura DTH, Dong W, Farias G, Thompson CC. Dose Response for Argon Plasma Coagulation in the Treatment of Weight Regain Following Roux-en-Y Gastric Bypass. Gastrointestinal Endoscopy. 2020 Jan 2. [Epub ahead of print]. PMID: 31904378.

SIS

De Moura DTH, Barrichello S Jr, de Moura EGH, de Souza TF, Dos Passos Galvão Neto M, Grecco E, Sander B, Hoff AC, Matz F, Ramos F, de Lima JHF, Teixeira L, Dib V, Falcão M, Potti H, Baretta G, Jirapinyo P, Thompson CC. Endoscopic sleeve gastroplasty in the management of weight regain after sleeve gastrectomy. Endoscopy. 2020 Jan 15. [Epub ahead of print]. PMID: 31940667.

Jirapinyo P, de Moura DTH, Thompson CC. Sleeve in Sleeve: Endoscopic Revision for Weight Regain after Sleeve Gastrectomy. VideoGIE. 2019;4(10):454-457. PMID: 31709328.

Endoscopic Management of Bariatric Surgical Complications

Chang SH, Popov VB, Thompson CC. Endoscopic balloon dilation for treatment of sleeve gastrectomy stenosis: a systematic review and meta-analysis. Gastrointest Endosc. 2019 Nov 28. [Epub ahead of print]. PMID: 31785274.

Dos Santos NT, De Moura DTH, Galvão Neto M, de Medeiros FS, Nogueira MVF, Thompson CC. Novel laparo-endoscopic hybrid procedure to treat a disconnected Roux limb after bariatric surgery. Endoscopy. 2019 Jun 7. doi: 10.1055/a-0885-9095. [Epub ahead of print] PubMed PMID: 31174217.

de Moura DTH, Ribeiro IB, Funari MP, Baptista A, Thompson CC, de Moura EGH. Novel use of a cardiac septal occluder to treat a chronic recalcitrant bariatric fistula after Roux-en-Y gastric bypass. Endoscopy. 2019 May;51(5):E111-E112. PubMed PMID: 30791049.

Hathorn KE, Jirapinyo P, Thompson CC. Endoscopic management of gastroesophageal reflux disease after sleeve gastrectomy by use of the antireflux mucosectomy procedure. VideoGIE. 2019 May 7;4(6):251-253. PubMed PMID: 31193837; PubMed Central PMCID: PMC6544871.

De Moura EGH, de Moura DTH, Sakai CM, Sagae V, Neto ACM, Thompson CC. Endoscopic Tunneled Stricturotomy with Full-Thickness Dissection in the Management of a Sleeve Gastrectomy Stenosis. Obes Surg. 2019 May 28. doi: 10.1007/s11695-019-03919-z. [Epub ahead of print] PubMed PMID: 31140166.

de Moura DTH, de Moura EGH, Neto MG, Jirapinyo P, Teixeira N, Orso I, Quadros LG, Amorim A, Medeiros F, Neto DR, de Siqueira Neto J, Albano A, de Sousa LH, Almeida D, Marchetti IA, Ivano F, de Lima JHF, Falcão M, Thompson CC. Outcomes of a novel bariatric stent in the management of sleeve gastrectomy leaks: a multicenter study. Surg Obes Relat Dis. 2019 May 22. pii: S1550-7289(19)30200-X. doi: 10.1016/j.soard.2019.05.022. [Epub ahead of print] PubMed PMID: 31262650.

Jirapinyo P, Makuvire TT, Dong WY, Chan WW, Thompson CC. Impact of Oral-Cecal Transit Time on the Interpretation of Lactulose Breath Tests After RYGB: a Personalized Approach to the Diagnosis of SIBO. Obes Surg. 2019 Jan 9. doi:10.1007/s11695-018-3575-3. [Epub ahead of print] PubMed PMID: 30627990.

Hourneaux de Moura DT, Jirapinyo P, Hathorn KE, Thompson CC. Use of a cardiac septal occluder in the treatment of a chronic GI fistula: What should we know before off-label use in the GI tract? VideoGIE. 2018 Dec 7;4(3):114-117. PubMed PMID: 30899887; PubMed Central PMCID: PMC6408700.

Baptista A, De Moura DTH, Jirapinyo P, De Moura EGH, Gelrud A, Kahaleh M, Salinas A, Sabagh LC, Jaramillo AO, Rincones VZ, Doval R, Bandel JW, Thompson CC. Efficacy of the cardiac septal occluder in the treatment of post-bariatric surgery leaks and fistulas. Gastrointest Endosc. 2018 Dec 6. pii: S0016-5107(18)33342-X. doi: 10.1016/j.gie.2018.11.034. [Epub ahead of print] PubMed PMID: 30529441.

de Moura DTH, Jirapinyo P, Aihara H, Thompson CC. Endoscopic tunneled stricturotomy in the treatment of stenosis after sleeve gastrectomy. VideoGIE. 2018 Nov 13;4(2):68-71. PubMed PMID: 30766946; PubMed Central PMCID: PMC6362310.

Schulman AR, Huseini M, Thompson CC. Endoscopic sleeve gastroplasty of the remnant stomach in Roux-en-Y gastric bypass: a novel approach to a gastrogastric fistula with weight regain. Endoscopy. 2018 Jun;50(6):E132-E133. PubMed PMID: 29566400.

Jirapinyo P, Thompson AC, Kröner PT, Chan WW, Thompson CC. Metabolic Effect of Foregut Exclusion Demonstrated by the Impact of Gastrogastric Fistula on Recurrence of Diabetes. J Am Coll Surg. 2018 Mar;226(3):259-266.e1. PubMed PMID: 29274838.

Schulman AR, Thompson CC. Abdominal Pain in the Roux-en-Y Gastric Bypass Patient. Am J Gastroenterol. 2018 Feb;113(2):161-166. PubMed PMID: 29016560.

Chiang AL, Storm AC, Aihara H, Thompson CC. Endoscopic full-thickness resection of fistula tract with suture closure. Endoscopy. 2018 Jan;50(1):E15-E16. PubMed PMID: 29069701.

Kumar N, Thompson CC. Remnant gastropathy due to bile reflux after Roux-en-Y gastric bypass: a unique cause of abdominal pain and successful treatment with ursodiol. Surg Endosc. 2017 Dec;31(12):5399-5402. PubMed PMID: 28799115.

Schulman AR, Thompson CC. Complications of Bariatric Surgery: What You Can Expect to See in Your GI Practice. Am J Gastroenterol. 2017 Nov;112(11):1640-1655. Review. PubMed PMID: 28809386.

Schulman AR, Thompson CC. Utility of Bile Acid Scintigraphy in the Diagnosis of Remnant Gastropathy in Patients with Roux-en-Y Gastric Bypass. Obes Surg. 2017 Oct;27(10):2750-2753. PubMed PMID: 28766266. PMCID: PMC5693743.

Storm AC, Thompson CC. Endoscopic Treatments Following Bariatric Surgery. Gastrointest Endosc Clin N Am. 2017 Apr;27(2):233-244. Review. PubMed PMID: 28292402.

Schulman AR, Chan W, Devery A, Ryan MB, Thompson CC. Opened Proton Pump Inhibitor Capsules Reduce Time to Healing Compared With Intact Capsules for Marginal Ulceration Following Roux-en-Y Gastric Bypass. Clin Gastroenterol Hepatol. Clin Gastroenterol Hepatol. 2017 Apr;15(4):494-500.e1. PubMed PMID: 27773764.

Schulman AR, Abougergi MS, Thompson CC. H. Pylori as a predictor of marginal ulceration: A nationwide analysis. Obesity (Silver Spring). 2017 Mar;25(3):522-526. PubMed PMID: 28229552

Thompson CC, Ryou MK, Kumar N, Slattery J, Aihara H, Ryan MB. Single-session EUS-guided transgastric ERCP in the gastric bypass patient. Gastrointest Endosc. 2014 Sep;80(3):517. PubMed PMID: 25028276.

Kumar N, Thompson CC. Endoscopic management of complications after gastrointestinal weight loss surgery. Clin Gastroenterol Hepatol. 2013 Apr;11(4):343-53. PubMed PMID: 23142331.

Kumar N, Thompson CC. Endoscopic therapy for postoperative leaks and fistulae. Gastrointest Endosc Clin N Am. 2013 Jan;23(1):123-36. PubMed PMID: 23168123.

Jirapinyo P, Watson RR, Thompson CC. Use of a novel endoscopic suturing device to treat recalcitrant marginal ulceration (with video). Gastrointest Endosc. 2012 Aug;76(2):435-9. PubMed PMID: 22658388.

Abu Dayyeh BK, Jirapinyo P, Weitzner Z, Barker C, Flicker MS, Lautz DB, Thompson CC. Endoscopic sclerotherapy for the treatment of weight regain after Roux-en-Y gastric bypass: outcomes, complications, and predictors of response in 575 procedures. Gastrointest Endosc. 2012 Aug;76(2):275-82. PubMed PMID: 22817783.

Watson RR, Braver JM, Thompson CC. EUS-guided transgastric upper GI series for the evaluation of the defunctionalized stomach after gastric bypass. Gastrointest Endosc. 2012 Jul;76(1):219-20. PubMed PMID: 21907983.

Puli SR, Spofford IS, Thompson CC. Use of self-expandable stents in the treatment of bariatric surgery leaks: a systematic review and meta-analysis. Gastrointest Endosc. 2012 Feb;75(2):287-93. PubMed PMID: 22047699.

Azagury DE, Abu Dayyeh BK, Greenwalt IT, Thompson CC. Marginal ulceration after Roux-en-Y gastric bypass surgery: characteristics, risk factors, treatment, and outcomes. Endoscopy. 2011 Nov;43(11):950-4. PubMed PMID: 21997722.

Flicker MS, Lautz DB, Thompson CC. Endoscopic management of gastrogastric fistulae does not increase complications at bariatric revision surgery. J Gastrointest Surg. 2011 Oct;15(10):1736-42. PubMed PMID: 21479671.

Ryou MK, Mogabgab O, Lautz DB, Thompson CC. Endoscopic foreign body removal for treatment of chronic abdominal pain in patients after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2010 Sep-Oct;6(5):526-31. PubMed PMID: 20870185.

Fernandez-Esparrach G, Lautz DB, Thompson CC. Endoscopic repair of gastrogastric fistula after Roux-en-Y gastric bypass: a less-invasive approach. Surg Obes Relat Dis. 2010 May-Jun;6(3):282-8. PubMed PMID: 20510291.

Offodile AC 2nd, Okafor P, Shaikh SN, Lautz D, Thompson CC. Duodenal obstruction due to erosion and migration of an adjustable gastric band: a novel endoscopic approach to management. Surg Obes Relat Dis. 2010 Mar 4;6(2):206-8. PubMed PMID: 20359671.

Fernández-Esparrach G, Lautz DB, Thompson CC. Peroral endoscopic anastomotic reduction improves intractable dumping syndrome in Roux-en-Y gastric bypass patients. Surg Obes Relat Dis. 2010 Jan-Feb;6(1):36-40. PubMed PMID: 19560979.

Merrifield BF, Lautz D, Thompson CC. Endoscopic repair of gastric leaks after Roux-en-Y gastric bypass: a less invasive approach. Gastrointest Endosc. 2006 Apr;63(4):710-4. PubMed PMID: 16564884.

Investigational Bariatric Endoscopic Devices

De Moura EGH, de Moura DTH, Galvão-Neto M, Sakai CM, Silva GLR, Bazarbashi AN, Thompson CC. Endoscopic Management of Anchor Erosion Adjacent to the Pylorus Following Duodenal-Jejunal Bypass Sleeve. Obes Surg. 2019 Jun;29(6):2003-2004 PubMed PMID: 30972635.

Haidry RJ, van Baar AC, Galvao Neto MP, Rajagopalan H, Caplan J, Levin PS, Bergman JJ, Rodriguez L, Deviere J, Thompson CC. Duodenal mucosal resurfacing: proof-of-concept, procedural development, and initial implementation in the clinical setting. Gastrointest Endosc. 2019 Mar 29. [Epub ahead of print] PubMed PMID: 30935932.

Jirapinyo P., Thompson C.C. Endoluminal Small Bowel Procedures for Obesity and Metabolic Diseases. In: Chand B. (eds) Endoscopy in Obesity Management. Springer, Cham; 2018.p. 167-71.

Jirapinyo P, Haas AV, Thompson CC. Effect of the Duodenal-Jejunal Bypass Liner on Glycemic Control in Patients With Type 2 Diabetes With Obesity: A Meta-analysis With Secondary Analysis on Weight Loss and Hormonal Changes. Diabetes Care. 2018 May;41(5):1106-1115. PMID: 29678867.

Machytka E, Bužga M, Zonca P, Lautz DB, Ryou M, Simonson DC, Thompson CC. Partial jejunal diversion using an incisionless magnetic anastomosis system: 1-year interim results in subjects with obesity and diabetes. Gastrointest Endosc. 2017 Nov;86(5):904-912. PubMed PMID: 28716404.

Rajagopalan H, Cherrington AD, Thompson CC, Kaplan LM, Rubino F, Mingrone G, Becerra P, Rodriguez P, Vignolo P, Caplan J, Rodriguez L, Galvao Neto MP. Endoscopic Duodenal Mucosal Resurfacing for the Treatment of Type 2 Diabetes: 6-Month Interim Analysis From the First-in-Human Proof-of-Concept Study. Diabetes Care. 2016 Dec;39(12):2254-2261. PubMed PMID: 27519448.

Ryou M, Agoston AT, Thompson CC. Endoscopic intestinal bypass creation by using self-assembling magnets in a porcine model. Gastrointest Endosc. 2016 Apr;83(4):821-5. PubMed PMID: 26522371.

Ryou M, Aihara H, Thompson CC. Minimally invasive entero-enteral dual-path bypass using self-assembling magnets. Surg Endosc. 2016 Feb 19. [Epub ahead of print] PubMed PMID: 26895911.

Other Bariatric-Related Publications

Runge T, Jirapinyo P, Chan WW, Thompson CC. Dysphagia Predicts Greater Weight Regain after Roux-en-Y Gastric Bypass: A Longitudinal Case-matched Study. SOARDS. 2019 Dec;15(12):2045-2051. PMID: 31931976.

McCarty TR, Jirapinyo P, Thompson CC. Effect of Sleeve Gastrectomy on Ghrelin, GLP-1, PYY, and GIP Gut Hormones: A Systematic Review and Meta-Analysis. Ann Surg. 2019 Oct 4. [Epub ahead of print]. PMID: 31592891.

Abidi W, Nestoridi E, Feldman H, Stefater M, Clish C, Thompson CC, Stylopoulos N. Differential Metabolomic Signatures in Patients with Weight Regain and Sustained Weight Loss After Gastric Bypass Surgery: A Pilot Study. Dig Dis Sci. 2019 Aug 5. [Epub ahead of print]. PMID: 31385097.

Castaneda D, Popov VB, Wander P, Thompson CC. Risk of Suicide and Self-harm Is Increased After Bariatric Surgery-a Systematic Review and Meta-analysis. Obes Surg. 2019 Jan;29(1):322-333. Review. PubMed PMID: 30343409.

Jirapinyo P, Thompson CC. Treatment of NASH with Gastric Bypass. Curr Gastroenterol Rep. 2018 Sep 22;20(10):49. Review. PubMed PMID: 30244334.

Ben-Zvi D, Meoli L, Abidi WM, Nestoridi E, Panciotti C, Castillo E, Pizarro P, Shirley E, Gourash WF, Thompson CC, Munoz R, Clish CB, Anafi RC, Courcoulas AP, Stylopoulos N. Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species. Cell Metab. 2018 Aug 7;28(2):310-323.e6. PubMed PMID: 30043755.

Chiang AL, Steiner G, Thompson CC. The Association of Bariatric Endoscopy as @ABEBariatric: an initial 9-month experience of establishing a professional society social media presence. Gastrointest Endosc. 2018 Jul;88(1):136-138. PubMed PMID: 29935609.

Jirapinyo P, Abu Dayyeh BK, Thompson CC. Weight regain after Roux-en-Y gastric bypass has a large negative impact on the Bariatric Quality of Life Index. BMJ Open Gastroenterol. 2017 Sep 11;4(1):e000153. eCollection 2017. PubMed PMID: 28944069; PubMed Central PMCID: PMC5596836.

Jirapinyo P, Jin DX, Qazi T, Mishra N, Thompson CC. A Meta-Analysis of GLP-1 After Roux-En-Y Gastric Bypass: Impact of Surgical Technique and Measurement Strategy. Obes Surg. 2018 Mar;28(3):615-626. PubMed PMID: 28871519.

Abu Dayyeh BK, Jirapinyo P, Thompson CC. Plasma Ghrelin Levels and Weight Regain After Roux-en-Y Gastric Bypass Surgery. Obes Surg. 2017 Apr;27(4):1031-1036. PubMed PMID: 27966064.

Jirapinyo P, Thompson CC. Sedation Challenges: Obesity and Sleep Apnea. Gastrointest Endosc Clin N Am. 2016 Jul;26(3):527-37. PubMed PMID: 27372775; PubMed Central PMCID: PMC4931551.

Lee A, Abidi WM, Thompson CC. Endoscopic reversal of Roux-en-Y gastric bypass. Gastrointest Endosc. 2015 Dec;82(6):1123. PubMed PMID: 26215647.

Jirapinyo P, Kumar N, Thompson CC. Patients with Roux-en-Y Gastric Bypass Require Increased Sedation During Upper Endoscopy. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1432-6. PubMed PMID: 25769410.

Jirapinyo P, Abu Dayyeh BK, Thompson CC. Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement. Dig Dis Sci. 2014 Sep;59(9):2173-7. PubMed PMID: 24723069.

Abu Dayyeh BK, Lautz DB, Thompson CC. Gastrojejunal Stoma Diameter Predicts Weight Regain after Roux-en-Y Gastric Bypass. Clin Gastroenterol Hepatol. 2011 Mar;9(3):228-33. PubMed PMID: 21092760.

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