The neuroendocrine system is composed of cells that are a cross between nerve cells and hormone-producing endocrine cells. Scattered throughout the body—including the lungs and the gastrointestinal tract—neuroendocrine cells regulate the flow of air and blood in the lungs and control the speed of digestion. Neuroendocrine tumors (NETs) form from neuroendocrine cells and can be either benign or cancerous.
Neuroendocrine tumors are usually classified as either pancreatic neuroendocrine tumors, also called pancreatic islet cell tumors, which develop in the pancreas, or neuroendocrine carcinoma (carcinoid tumors) that start in other parts of the body. Carcinoid tumors are most often found in the digestive system since it is large and has the most neuroendocrine cells in the body. Gastrointestinal carcinoid tumors form in the lining of the gastrointestinal tract, typically in the appendix, small intestine or rectum. Gastrointestinal carcinoid tumors are uncommon and tend to grow slowly.
Though neuroendocrine tumors are rare, they are on the rise, with the incidence of these types of tumors increasing over the past few decades. Despite this rarity, surgeons at Brigham and Women’s Hospital (BWH) are experienced in diagnosing and treating patients with neuroendocrine tumors. Our surgeons work with a team of medical experts in the Program of Neuroendocrine and Carcinoid Tumors at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), combining their specialized knowledge to offer multidisciplinary cancer care for patients.
Our board certified surgeons perform a large volume of minimally invasive approaches, such as laparoscopic and robotic surgery, to surgically remove neuroendocrine tumors.
Our surgeons are experts in diagnosing and treating patients with the following types of neuroendocrine tumors:
Pancreatic neuroendocrine tumors, also called pancreatic islet cell tumors and pancreatic carcinoid, are rare types of hormone-producing tumors that form in tissues of the pancreas. Learn more about pancreatic neuroendocrine tumors.
Neuroendocrine carcinoma Also referred to as carcinoid tumors, these tumors arise throughout the body and are classified by their site of origin:
Other types of neuroendocrine tumors include:
In rare cases, neuroendocrine tumors may be inherited but, for the majority of neuroendocrine tumors, no clear cause has been identified. Researchers in the Program of Neuroendocrine and Carcinoid Tumors at the Dana Farber/Brigham and Women’s Cancer Center are currently actively investigating potential environmental or genetic causes for neuroendocrine tumors.
Carcinoid tumors are often found during tests or treatments for other conditions and sometimes a patient has no symptoms. Alert your doctor if you experience any of the following symptoms:
Learn more about symptoms of pancreatic islet cell tumor, a type of neuroendocrine tumor.
A range of test and procedures may be performed to diagnose neuroendocrine tumors:
Learn about diagnostic tests for pancreatic islet cell tumors, a type of neuroendocrine tumor.
After a neuroendocrine tumor has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body.
There is no standard staging system for a neuroendocrine tumor. The stages used to describe a pancreatic neuroendocrine tumor are the same as the stages for pancreatic cancer.
Source: National Cancer Institute.
Our surgeons offer extensive expertise in the most advanced minimally invasive surgical procedures for neuroendocrine tumors. When neuroendocrine tumors are detected at an early stage, they can usually be removed surgically. In most cases, post-surgical treatment with chemotherapy or radiation therapy is not necessary, and patients can be monitored with blood tests and scans.
One of the following surgical procedures may be used:
Learn about surgery for pancreatic islet cell tumors, a type of neuroendocrine tumor.
You will receive a thorough diagnostic examination to evaluate if you have a neuroendocrine tumor and determine what course of treatment is needed. Careful monitoring and the involvement of an experienced surgeon are important to successful outcomes for patients.
If you are having surgery or a procedure, you will likely be scheduled for a visit to the Weiner Center for Preoperative Evaluation for pre-operative information and tests.
The day of surgery, you will be cared for in the operating room by surgeons, anesthesiologists and nurses who specialize in neuroendocrine tumor surgery. After surgery, you will recover in the post-surgical care unit where you will receive comprehensive care by an experienced surgical and nursing staff.
The Program of Neuroendocrine and Carcinoid Tumors at the Gastrointestinal Cancer Treatment Center at Dana-Farber/Brigham and Women’s Cancer Center provides advanced and innovative multidisciplinary care for patients with neuroendocrine tumors. Our treatment team includes surgeons, medical and radiation oncologists, pathologists, radiologists, anesthesiologists, gastroenterologists and nursing and research staff. In addition, patients have full access to BWH’s world-renowned academic medical community with its diverse specialists and state-of-the-art facilities.
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